Proxalutamide clinical trial?

After a good 3 year run on Xtandi, my husband's PSA has risen to 38 and it's time to change treatment. (Dx 2015, mets to bone, Gleason 9 on Lupron injections, has had radiation, one Taxotere infusion, couldn't tolerate) his MO suggested today a clinical trial for Proxalutamide. Would appreciate feedback on it. Side effects? Did it work for you? How it compares to Xtandi?

[Tall_Allen]

FWIW, here's what I have in my files:

cancerres.aacrjournals.org/...

"No dose limiting toxicity was observed. Maximum tolerated dose was not reached. GT0918-related adverse events were relatively mild (CTCAE grade 1 or 2), including hypercholesterolemia, peripheral edma, fatigue, flush, constipation and anorexia. "

ascopubs.org/doi/abs/10.120...

"No Dose Limiting Toxicity was observed and Max Tolerated Dose has not been reached. GT0918 related adverse events (AEs) were less than 10% and grade 1 or 2 as per CTCAE v4.03, including fatigue, nausea, dizziness, loss of appetite, back pain, hot flush, hypercholesterolemia, anemia, constipation, etc. Two events of grade 3 fatigue and one event of grade 4 elevated creatine kinase (CK) were reported.

ascopubs.org/doi/abs/10.120...

So, it looks like good stuff. Please report back how it goes.

[Hidden in reply to Tall_Allen]

Thank you Tall Allen for the information and responding to my post. I will update how he does. I am thankful there are new treatments to try and my husband is being accepted into this trial.

[j-o-h-n in reply to Hidden]

To Yellowlab, Hope he does well in the trial. If for any reason he's having problems with driving make sure he takes a YellowCab home....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 11/14/2019 7:58 PM EST

[Hidden in reply to j-o-h-n]

You always crack me up! Thanks!