Anyone had radiation treatment for this? How effective is it? Typical side effects? Is there an optimal time to radiate? I will likely return to Lupron when my PSA starts to rise.
I stopped Lupron and Xtandi one year ago. My testosterone returned at 236 four months later (April) and has continued to rise to 344 two weeks ago. I have never been on Casodex.
I have developed pain and swelling over the past 6 weeks.
Is this all physiologic? I did have the same at puberty and my doctor then said it would go away. It did.
I would like to avoid beasts if possible.
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chipler
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Radiation treatment could be effective when used before the gynecosmatia develops. Once it is present and causing symptoms, radiation could help to reduce symptoms.
The problem with Tamoxifen is that there are not data about the effects of chronic administration of Tamoxifen to patients requiring ADT and/or anti androgens for the rest of their life.
"Conclusions: The currently available evidence suggests good efficacy of tamoxifen for the prevention and
treatment of breast events induced by non-steroidal antiandrogens. The impact of tamoxifen therapy on long-term adverse events, disease progression and survival remains unclear. Further large, well-designed RCTs, including long term follow-ups, are warranted. Also, the optimal dose needs to be clarified"
Perhaps you know of studies with long term follow up ( 10 or more years) showing that taken Tamoxifen chronically does not cause adverse events in the control of the cancer and in the overall health of the patients.
Tamoxifen is an old drug. Women have been taking it for many years, and continue to do so. In women with metastatic breast cancer, there was a small danger of endometrial cancer, and possibly blood clots.
What is the long-term effect of radiation to the chest? Do low levels of radiation hitting the heart or the lungs have any long-term effect on cardiac or pulmonary function? From the citation you just gave, it reads:
"However, Nieder et al. provided data demonstrating that exposing the heart to prophylactic radiotherapy of the mammillary region might contribute to cardiac side effects [35]. A narrative review evaluating safety and tolerability did not conclude either these cardiac side effects or secondary malignancies or pulmonary events, but it noted that no studies have evaluated the long-term effects of radiotherapy in men [34]."
At low doses, tamoxifen is an estrogen agonist in most tissues, but an estrogen antagonist in breast tissue. As you may know, estrogen was the first prostate cancer medicine, and is being revisited now in major clinical trials now that transdermal forms are available that don't cause the same level of blood clots. It is certainly a good idea for those taking tamoxifen to monitor clotting factors in the blood.
It has been tried as a medicine for prostate cancer. It had some effectiveness in this Phase 2 trial:
At some point, we make what seems like a reasonable decision based on available evidence. It certainly seems to be safe, is twice as effective as chest radiation, and may even confer a small oncological benefit.
Tamoxifen is great stuff. I love it. Besides eliminating the painful nodules, side effects include reduced belly fat, and muscle gains. Normally it's the T/E ratio that's important in body composition - but if the T is effectively zero, you need to do something to mitigate the E. Tamoxifen is a selective estrogen receptor modulator (SERM). It's an estrogen receptor agonist were you need it (bones), and an antagonist were you need it (boobs). Magical.
I had radiation prior to ADT to prevent this!!! When my man boobs grew, I asked my Oncologist who said nothing more could be done!!!
Now reading that yet another drug may help!! F&$# the drugs!!!!
I get out of the shower, look in the mirror.....it aint my tits that upset me!
Took a long time but, I get it... my body is changed, my life has changed and neither for the better!!! But my life is spared!!!
Grandkids certainly are the worse!!! They run up and jump on you, then its ow-f&$#ing-wa!!!! I tell them not to touch me there, smack them around a bit and get on with it!!!
I show mine off at dinner parties! “Here, hold my cummerbund and look at these babies”!!!!
The pain in nipples stops and breasts grow if you gain weight just like a woman who is overweight.
I have small perky breasts now that I’ve lost 30 lbs. I don’t like them but I haven’t made a plan to get breast reduction surgery. I think it’s too late for radiation for my breasts.
Worked like a charm for me. Casodex was actually growing breast tissue (you can feel the difference from muscle) and my nipples were changing fast (scary~!). And they hurt like hell.
Three sessions on each, beam angled from the side to miss internal organs. Within a week or so, no more pain, nipples back to normal and breast tissue gone.
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