Taxotere and elevated liver tests

[dunde8889]

Can taxotere be used with high liver tests due to spread of cancer to the liver? The oncologist is going to use jevtana because of it. My dad doesn’t have any liver issues before the cancer spread to the liver. The liver tests are ALT 190 AST 140 bilirubin is normal.

[tango65]

Taxotere is associated with elevation of liver enzymes:

livertox.nih.gov/Docetaxel.htm

It seems Jevtana rarely causes elevation of liver enzymes.

livertox.nih.gov/Cabazitaxe...

[dunde8889 in reply to tango65]

I figured that’s why he changed. I’ve read other people here getting taxotere with liver metastasis so was curious if taxotere could still be given

[Tall_Allen]

Why don't you want him to have Jevtana? Cost? Jevtana+Carboplatin followed by a PARP inhibitor is the subject of a trial at MD Anderson for men with APC that has particularly aggressive features. If he qualifies, he will get those drugs for free:

clinicaltrials.gov/ct2/show...

[dunde8889 in reply to Tall_Allen]

No it’s not about cost. Just concerned since it’s second line to taxotere. I was wondering if it’s as effective as taxotere. My dad hasn’t received any chemo yet and this is the first time.

I read the link you provided. For these studies do they allow you to get the chemo at a different hospital? And then use the trial med if he is the right group after. Since we are on the west coast it would be tough to fly every few weeks for chemo.

[Tall_Allen in reply to dunde8889]

I don't know - call them. You can probably get Jevtana and carboplatin without the clinical trial. Insurance would probably not approve olaparib off label.