This is my first post but I’ve been reading for a month or so. I appreciate the support and information that can be given here. My dad was diagnosed in November, age 66, with advanced prostate cancer with Gleason of 8, psa in the 500’s and no bone Mets but spreading to the distant lymph nodes. The plan was to go on Lupron plus zytiga/prednisone. The Lupron is working and his most recent tests show a psa around 3. The zytiga however has caused his liver enzymes to go up. We are now on a lower dose of zytiga 750mg and after two weeks one liver enzyme has again gone up above 100 (upper end of normal is 55). The first time he started zytiga in January he was on Crestor but the second time he was not. Has anyone else experienced this? Did you try any other course of treatment? How low of a zytiga dosage can be taken and still have the same effect, as per the stampede trial? On the positive side my dad feels really good and continues to live every day to the fullest.