Zytiga

[Chris52981]

Is it normal for PSA to go from 2.38 to .50 in two

Months since on Zytiga and lupron or should it be undectable

[LearnAll]

YES...It will probably go to 0.2 in next 2 or 3 months. Good news !

If you still have prostate intact then 0.2 is considered undetectable.

[Chris52981 in reply to LearnAll]

Thank God and I hope!

[Hidden]

It took me 4 months for Zytiga to take my PSA down from 2.35 to <0.1, where it remains.

[Tall_Allen]

Yes, that's normal. Sometimes it can become undetectable, sometimes not. But that's an excellent response.

[DarkEnergy in reply to Tall_Allen]

Hi TA,

I've been thinking of "undetectable", which is my situation with PSA <0.02. Does reaching and holding PSA undetectable reading means metastasis free? Or the cancer cells are in a dormant state, thus not expressing PSA?

Moreover, do we really know?

[Tall_Allen in reply to DarkEnergy]

"Does reaching and holding PSA undetectable reading means metastasis free?" Unfortunately not - it does not necessarily mean either metastasis-free or dormant. Perhaps this article will clear up your misunderstanding:

prostatecancer.news/2020/07...

[Wings-of-Eagles in reply to Tall_Allen]

Thanks for that link,Tall One!

From Winged one

[Chask]

I started on Zytiga in July 2018 when my PSA was .46. I never got below that and in fact jumped up to .86 and never got below .8.

There was a long slow progression up to 4.00 in September 2020.

Unfortunately it now seems to have failed and PSA has jumped to 10 in just 2 months, and that is after switching from Prednisone to Dexamathasone.

See Onco in a cupla days. Expecting new bone scan, possibly radiation and start of Chemo.

[Lettuce231]

Great Wes, it's working well Chris. Hope you have a merry Christmas now 😊

Phil

[Haniff]

Hi Chris

I have been on Zytiga for the last 5 months but my PSA decline has been very very slow. It went from 27.6 to now only at 26.1 hahaha

But I am taking it with a pinch of salt and keeping my fingers cross that my PSA will decline to lower digits when my next blood work comes up on 15 December. You, on the other hand have done very well, my very best to you and enjoy the good tidings

❤️

Haniff

[j-o-h-n]

Good news..... is easy to swallow...........Have a nice Chris-tmas....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 11/18/2020 11:33 AM EST

[kayak212]

Having never had treatment for my PCa I am unfamiliar with any of the many different medications i see discussed on these posts ...e.g. Lupron, Zytiga etc. Where would be a good online source for me to educate myself about them? Thanks.

[treedown in reply to kayak212]

Your on it. Use the search function. NCCN Guideline website might help understand which are used and when.