Hey gang, saw this paper about AMPK activation, which Metformin does, and the effect on PCa:
ncbi.nlm.nih.gov/pmc/articl...
But, also saw this one about IF (Intermittent fasting) and AMPK:
siimland.com/how-to-increas...
BTW, safe in CA, the quakes were 100s of miles from us. Still felt like we were on a boat for over a minute. Ridgecrest is about 77 miles from my dental office, web cams showed no damage.
Fight on
Randy
never nausea because of 2g metformin?
Thanks for posting Randy... I’m doing IF, berberin, ACV, plus lots of sport, and lipid tests have improved—triglycerides have dropped from 75 to 45 in six months, and HDL increased from 50 to 65. There was a little shaking from the quake down here in San Diego, glad you had no damage, mag 7.1 is quite a hit
Sweet, I hope that you've had good results from that combo. There's a ZERO 5k event, if you didn't know, on 09/21 in SD. I'm off to NYC to do that 5k with my Bro in law - also a PCa survivor on 0922. Also I'm doing the NYC marathon again for the 4th time this Nov.
My best to you Brother
Great, thanks for the heads-up on the Zero 5K in SD. Hope your 5K in NYC goes well and best wishes for a good NYC-M, that's a great event I've heard from friends. Just finished a 4-mile run, drinking ACV, and going into IF. Keep up all the good energy and thoughts! Best- Tim
Thanks for posting, Randy...
I do IF and Berberine, and Tumeric. Trying to get metformin next visit. Keep running and keep fighting....
Fish
Het NPfisherman,
LifeExtension has an AMPK activator. Give it a read.
Currumpaw
Fish:
Does Metformin offer an advantage over Berberine? Is your reason for these primarily AMPK activation?
Also, what does your IF schedule look like?
Thanks. Happy Sunday brother,
Josh
Hi, I do IF from 9pm to 1pm the next day. I have black coffee, green tea and homemade curry, tomato, and veggie broth whilst fasting.
My best to you
Randy
Hey my man,
I would do metformin but getting the Rx is the issue from my MD's...I may bypass them as I have a connection for Metformin from overseas... I would take both....Nalakrats does...my IF schedule is similar to dockam's....I start eating at around noon or 1 pm and stop at 9 pm...I drink water, V8 juice, Green tea, or Kombucha while fasting ...
Hope you are having a good weekend....
Fish
I got my Metformin through a clinical trial at Winthrop Hospital in Long Island, NY (NCT02176161). I didn't have to go there in person. They mailed me the Metformin. That and other trials are recruiting now, according to clinicaltrials.gov. Once the trial was over, I had trouble getting a Rx for Metformin from any of my doctors in Kaiser Permanente. So, I coughed up the private pay fee and went to the local urgent care clinic, and got the Rx. Metformin is cheap. It cost me $17 for a 90 day supply of 2 extended release tabs per day at Costco, with no insurance. I've since got divorced from Kaiser, and now get it paid for by Medicare and secondary insurance.
Here is an article about AMPK, with a lot of natural AMPK activators listed.
selfhacked.com/blog/natural...
-Capt. Dave
Berberine is as effective as Metforman by improves lipid profile better.
2000 mg daily going on 50 months for me, part of the multi dimensional Dr. Myers approach.
BTW heading south to do some fishing for a couple weeks tomorrow.
Ed
The ncbi link contains this passage:
"In the case of prostate cancer AMPK activation may be associated with poor prognosis. Ca2+/CaM-dependent protein kinase kinase β (CaMKKβ) is elevated and correlated with prostate cancer cell migration and proliferation. Recall that CaMKKβ is an upstream activator of AMPK. Inhibition of CaMKII activity by synthetic agents has been shown to suppress prostate cancer cell growth [145]. CaMKKβ-induced prostate cancer cell migration requires AMPK activation [58] and blocking CaMKK/AMPK pathway results to the inhibition of prostate cancer cell growth."
I saw that. Trying to get my head around this whole AMPK activation thing... including the Metformin and Berberine discussion. Consider adding what seems to be unequivocally beneficial and obviously avoid what we believe to be harmful. As for the other stuff, like AMPK activators, there is some ambiguity that makes me hesitate.
I appreciate all the research and thoughts shared in this and other posts. It helps in the evaluation.
I believe in the Four Horsemen of the Apocalypse that we call PCa. I try and deal with them accordingly....1) Inflammation--many of my supplements as well as ASA and other things deal with inflammation, 2) Glycolysis-- I take Berberine currently and will be working on a supply to add Metformin, 3) Cholesterol-- I am on a Statin and will add Bempedoic acid when approved--an ACLY blocker that will slow tumorigenesis, and 4) Hormones--Zytiga, prednisone, Lupron, and DIM....
Reading Friedman now.....liking it so far....
Fish
I’ll let you know how it goes
Hopefully I’ll have something worthwhile to share, if I do I’ll send it via PM
Just think with earthquakes in your dental office.... there's no need for a drills.......
Keep on running....
Good Luck, Good Health and Good Humor.
j-o-h-n Sunday 07/07/2019 6:23 PM DST
It seems strange that many of the natural AMPK activator supplements, and fasting, and exercise, which seem be cancer suppressors, are also autophagy activators.
According to current theory, autophagy promotes existing PCa.
Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components.........this promotes cancer?
In my opinion, something is off here.
Doug
Yea this article discusses both promotion/suppression:
Do medium-chain triglycerides downregulate mTOR?
Sea Cucumbers and their cytotoxic effect on PCa. 
Mushrooms use in PCa
