Curious how many are taking Arimidex with ADT

[George71]

Are you taking Arimidex with ADT

[pjoshea13]

George,

Arimidex is used to control elevated estradiol [E2]. The usual dose is 0.5 mg three times weekly.

For many men, E2 & T (testosterone) go in opposite directions, except that E2 is not a problem for men with high-normal T.

With the metabolic syndrome [MetS], there is more chance of T being close to the T cutoff for hypogonadism (350 ng/dL) & E2 being above 30 pg/mL.

But E2 is mostly produced by the aromatization of T, and with ADT, E2 is generally <20 pg/mL. (There is no need for Arimidex unless E2 is >30 pg/mL.)

In fact, if E2 falls below 12 pg/mL, a low-dose E2 patch should be used to bring E2 up. I would use 20 pg/mL as the target. It might not be necessary to use a daily patch to achieve that.

-Patrick

[NPfisherman in reply to pjoshea13]

Thanks for this reply--I had a recent E2 level of 5....will discuss with my MO next visit....

Fish

[Tall_Allen]

Not a good idea- estrogen is especially important for bone health, lean muscle mass, and controlling hot flashes when on ADT.