Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

[George71]

Jun 14 2019

"What's good for our bones may also help stop cancer cells that develop resistance to multiple chemotherapy drugs.

The vitamin D metabolite calcitriol and its analog calcipotriol can block one of the mechanisms through which cancer cells gain resistance to chemotherapy drugs-;and can selectively kill those drug-resistant cells, according to Assistant Professor Surtaj Hussain Iram of the South Dakota State University Department of Chemistry and Biochemistry.

His research focuses on drug transporter proteins, which are the key determinants of drug absorption, distribution and excretion from the body. Overexpression of drug transporter proteins is the most frequent mechanism through which cancer cells gain resistance.

Several epidemiologic and preclinical studies show the positive effect of vitamin D in reducing cancer risk and progression, but we are the first to discover its interaction with drug transporter protein and its ability to selectively kill drug-resistant cancer cells."

Surtaj Hussain Iram, Assistant Professor, South Dakota State University

Furthermore, most drug discovery projects focus on killing cancer cells but eventually they gain resistance to chemotherapy drugs, he explained. "The vitamin D metabolite and its analog cannot kill the naive cancer cells, but when those cells develop resistance, calcitriol and calcipotriol can kill them."

The study results were published in Drug Metabolism and Disposition, a journal of the American Society of Pharmacology and Experimental Therapeutics. "The paper was picked as the best of the issue and was featured on the cover," Iram said. "This is an extraordinary experience for an assistant professor. We are getting the SDSU name out there."

Postdoctoral researcher Kee W. Tan and doctoral students Bremansu Osa-Andrews and Angelina Sampson also worked on the study."

news-medical.net/news/20190...

[NPfisherman]

Thanks for posting, George....I am a fan of Vitamin D--got a level today....on 20K a day...

Fish

[George71 in reply to NPfisherman]

Hi Fish,

Me too, I upped my dose to 20k a couple days ago.

[cesanon in reply to George71]

Isn't that a bit high? At some point its starts to cause damage, doesn't it.

Are you getting your vitamin D blood levels tested? If so what kind of lab results are you getting?

[George71 in reply to cesanon]

I haven't had it checked lately -- last time it was around 60.

You get around 25,000 in an hour in the sun.

[cesanon in reply to George71]

60 is a nice level. That is about what mine is. Though I only take 2000 units of Vitamin D 3 times per week.

I think the blood levels of Vitamin D are more important than the amount you are taking.

[HOPEFULSPOUSE in reply to NPfisherman]

at 20K daily - how often do you monitor your levels / what are your target levels? My husband takes 10K a day to maintain between 80-100, now wondering if he should up it?

[HOPEFULSPOUSE]

So interesting - thanks for posting!

[HOPEFULSPOUSE]

Thank you! Good to know. If Nalakrats is doing 20 that is worth exploring.

[NPfisherman in reply to HOPEFULSPOUSE]

No....he advised me to do 20K... I have NO idea how much he does ....and he sunbathes too....out fishing.... You would have to ask him how much he takes.... whatever he does, it is working....he has the worst mutation--PTEN-- and has been "undetectable" for 4 years....hope I go undetectable for 4 years....a blessing from God.....

Fish

[HOPEFULSPOUSE in reply to NPfisherman]

Sounds good - my husband will look into whether or not he is taking enough. Yes Nalakrat's story is remarkable - he needs to write a book!

[Hidden in reply to HOPEFULSPOUSE]

Vit d drops are cheap and easy ..

[Hidden]

We all are d deficient ,even the well tanned guy ... we need d....

[HOPEFULSPOUSE in reply to Hidden]

What’s a dangerous level? I was 142 last month. So I have stopped for 4 weeks now. Will wait to end of summer before getting test again.

[Hidden]

Nal has an all out routine mastered ..,

[Hidden]

I don’t the figures , but too high isn’t good either .. I need to do a test also .

[j-o-h-n]

I'll be a pun of a Sun, Vitamin D again?

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/19/2019 6:12 PM DST