new treatment started

[elainea53]

My husband is now on Cabazitaxel and Carboplatin and prednisone.

He is in a randomized trial at MDA and the drug in the trial is Olaparib.

After 6 of the two chemos which are soc he is randamized to either get the Olaparib or not. Our local oncologist wants to try to get the Olaparib so we would not have to worry if he is getting it in the trial. He told us that men on Medicare have a harder time getting it. We have United Health thru aarp.

Has anyone gotten that drug thru them. does anyone know if this is a drug to pursue.

He was doing well and then the tumor markers went up even thought a 0 psa. Also other labs are worse. He has had one session of the two chemos and tomorrow gets session 2. He actually feels good.

Any help or ideas are appreciated. Someone told me that Dr. Sher at MSK had some kind of magic bullet treatment, however he is not taking new patients.

thanks so much for any help.

[Tall_Allen]

Olaparib is not approved for prostate cancer yet. Based on the new published trial (below), it may be approved soon in men who are BRCA positive:

nejm.org/doi/full/10.1056/n...

There is a question as to whether a PARP inhibitor is better or worse than carboplatin, or if they work better if used together, in men who are BRCA positive. Clinical trials, like the one at MDA, will someday clear that up.

[elainea53 in reply to Tall_Allen]

He does not have the BRCA mutation. He does have the Jacks.

[Tall_Allen in reply to elainea53]

Since there is no evidence that a PARP inhibitor does anything for men with JAK2 mutation, why not see what the carboplatin does for it first?

[elainea53 in reply to Tall_Allen]

He is on the carboplatin

[Tall_Allen in reply to elainea53]

Is it working?

[Drcrunch]

AARP Medicare part d will not approve it for prostate cancer . Was denied.

[elainea53 in reply to Drcrunch]

Do you have any idea how much it costs.

[Drcrunch in reply to elainea53]

14,000. Per month

[elainea53 in reply to Drcrunch]

Whoooo, you did mean 14,000. I don't know if it is proven to work or how many treatment it would take.

I would consider anything to keep my husband alive .

[GP24]

There is no magic bullet treatment for prostate cancer. Howard Scher is an excellent doctor but he does not have a magic bullet.

[vandy69]

I was diagnosed with ATM defect from Guardant360 liquid biopsy and Dr. Snuffy Myers prescribed Lynparza. AARP/United HealthCare approved it and it worked for me for about 9 months.

Best wishes. Never Give In.

Mark, Atlanta

[elainea53 in reply to vandy69]

What did u do after the 9 months.

I don’t know what Lynparza is.

We are also in Atlanta

[vandy69 in reply to elainea53]

Lynparza is Olaparib. After Lynparza failed, I tried BAT, but it did not work. Next diagnosed with prostate cancer mets in my liver, so immediately began chemo with Docetaxel/Carboplatin. More after all of this.

Being in Atlanta, my Medical Oncologist is Dr. Vasily Assikis at Piedmont Cancer Institute.

Mark

[j-o-h-n]

Sorry NO magic bullets for Pca... I've think I've seen posts here that Dr. Scher is NOT taking on new patients, but call his office and ask (I think the call is free 👀).

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/12/2019 6:47 PM DST

[elainea53 in reply to j-o-h-n]

We called and you are correct he isn’t taking new patients.

[j-o-h-n in reply to elainea53]

Try Dr. Michael Morris at MSKcc.... he's very good.... I think he's only taking on difficult patients (not personality difficult 👀 - clinical).

BTW did Dr. Scher's office recommend anyone else?

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 06/12/2019 8:07 PM DST

[elainea53 in reply to j-o-h-n]

No he did not recommend anyone. I have heard the name Michael Morris.

thanks

[elainea53]

Thanks