Rising psa on chemo, exhausted standard of care treatments

[joann48]

My husband who was dx in August 2016 and has many different treatments . He was currently receiving Cabazataxel for 3 treamtnents following 4 treatments of docataxel. His Psa has risen to 135 , 40 points hgh in the last three weeks. Help, we are crazed not knowing what to do next. However, he very rarely has any pain, We are meeting with another MOC to find out about a trial they are offering. Not sure he is elgible. Looking for any suggestions. Thank you

[Magnus1964]

Has he been on any ADT drugs? These could provide many years quality life.

[joann48 in reply to Magnus1964]

Yes Brandi and xytiga. Both failed also xofigo for 6 treatments

[Magnus1964 in reply to joann48]

Has he had or has is doctor mentioned zytiga or casodex?

[Fairwind]

Give the Jevtana (Cabazitaxel) a chance. These things take a little time..What is his testosterone number ? In some men the Lupron type drugs don't work as expected. Has he tried Zytiga ? See if the "Vision" trial (Lu-177) is being conducted at a location near you. If so, work on that as there are lots of hoops to jump through and it takes time...

[Tall_Allen]

Has he tried Xofigo?

[joann48]

yes, over a year ago.

[G2779]

Hi joann48

Just curious to know what was your next step you took, my dad same boat now ? Can please advise