I have wrapped up 6 rounds of chemo while taking a monthly Lupron injection since November. My PAA has dropped to a .1, should I take a Lupron break? I have been on and off Lupron for the last three years and it kicks my butt, but it works on keeping my PSA suppressed. Each break gets shorter with increased velocity and doubling time. Should I risk taking a break or suck it up. It has been three years since my RP surgery followed by 38 rounds of radiation with Lupron. Stage 4 with Lymph node Mets.