EAU19 Barcelona – 15-19 March 2019 - Sentinel Scores.

[pjoshea13]

We are 30 years into the PSA era. I was diagnosed half-way in - 15 years ago - & no-one seemed happy with the PSA/biopsy model back then.

Laurence Klotz started writing about active surveillance [AS] at about that time, & has over 100 papers on the subject. He may have invented the term, although Chris Parker at the Royal Marsden also had a paper with the same title at that time. Klotz has a paper out this month: "Active surveillance in intermediate risk prostate cancer" & he still seems to be at the Division of Urology, Sunnybrook Health Sciences Centre, Toronto. But I suspect he is the same "Dr. Laurence Klotz, MD, FRCSC, CM, miR Scientific’s Chief Medical Officer", currently in Barcelona, where he presented:

"a non-invasive screening liquid biopsy urine test that identifies clinically significant prostate cancer and detects the presence of higher-grade cancer in men on active surveillance".

Some will be cynical of the profit motive, perhaps, but I think he brings a lot of credibility to the product.

Over 25% of men on AS in the U.S. will progress & should not be on AS IMO.

biospace.com/article/releas...

-Patrick

[NPfisherman]

Patrick, thank you for posting this information... I think the vast majority of us feel like AS is nothing more than a delay to treatment overall and a death sentence for many....especially for higher gleason scores... no one should screw around with the beast... How many have lost their lives due to AS... cost of evaluation be damned...it's about lives.... This test should help... I am thankful this technology will be available to others.... maybe if I had this, then I might not be here...delay in biopsy of 6 months...

All the best,

Fish

[Shooter1]

Urine test instead of biopsies sounds great to me.

[snoraste]

It's the same Dr. Klotz.

[PhilipSZacarias]

You are correct Patrick, Dr. Klotz’s first name is Lawrence and he is at the Sunnybrook hospital in Toronto. This is the hospital where I had my SBRT performed. Dr. Klotz performed a prostatectomy on my brother and saved his life.

[PhilipSZacarias]

I believe a urine based test for PCa is the way to go for surveillance. I don’t think Klotz would support the technology if it didn’t have scientific validity or merit

[PhilipSZacarias]

There is a recent paper in the journal European Urology that might be interesting.urotoday.com/recent-abstrac...