Systemic Lupus Erythematosus (SLE) & PCa - Advanced Prostate...

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Systemic Lupus Erythematosus (SLE) & PCa

pjoshea13
pjoshea13

New study.

"Our results shed light SLE being correlated with increased risk for 16 involved cancers and decreased risk for prostate cancer and cutaneous melanoma."

More: "non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, leukemia, multiple myeloma, cervix, vagina/vulva, renal, bladder, esophagus, gastric, hepatobiliary, lung, oropharynx, larynx, non-melanoma skin, and thyroid cancers"

... but less PCa!

Go figure.

...

I remember an old article on the flu shot that said that men with normal-high testosterone seem not to benefit. The reason being that testosterone [T] dampens the immune response, so less antibodies are produced.

The piece hypothesized that ancient man might have benefited, in that with some common injuries you don't want a vigorous immune response.

The price women pay for having a stronger immune system is a greater chance of autoimmune diseases - such as Lupus.

So men with normal T have a very low risk of lupus. But men with low T have increased risk of aggressive PCa. So why would SLE lower the PCa risk?

It might be a function of hw low the T is. "... testosterone inhibits the survival of B-cells, which are responsible for producing the autoantibodies that attack the body’s own tissues in autoimmune diseases." The quote is from an article about a 2018 study: "Testosterone is an endogenous regulator of BAFF and splenic B cell number" [2]:

"Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an α-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity."

-Patrick

[1] arthritis-research.biomedce...

[2] nature.com/articles/s41467-...

1 Reply
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Got a friend at work with SLE and that's no pleasure cruise either.... not any great treatment ... methotrexate, steroids....they do have clinical trials for SLE but a long way away on a real answer...

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