Any ideas why.............? - Advanced Prostate...

Advanced Prostate Cancer

20,782 members25,886 posts

Any ideas why.............?

alephnull profile image
6 Replies

All, My PSA when on ADT is usually at 0.09. It never deviates more than a hundredth.

In December my PSA went up to 0.19 and at that time I received yet another ADT shot.

Okay, so maybe I'm now castrate resistant???

Fast forward to yesterday (35 days later), PSA dropped ever so slightly to 0.17.

I'll say it again, while on ADT, my PSA never deviated by more than 0.01 or so.

So, I'm curious why would my PSA sudenly act like this, double and then remain relatively steady. If I'm CR, then it should continue to go up. My thoughts are that the hospital had either re-calibrated the equipment or purchased a new testing device. And both of these ideas could explain this.

Written by
alephnull profile image
alephnull
To view profiles and participate in discussions please or .
Read more about...
6 Replies
Jimhoy profile image
Jimhoy

Did they test “T” levels? Are you still and did you remained castrated through there PSA tests?

Tall_Allen profile image
Tall_Allen

Castration resistance is a relative term (not binary). The cancer may be more active some times than others. You should ignore anything beyond the first decimal.

Magnus1964 profile image
Magnus1964

The increase could be caused by an infection or inflammation in the prostate area. Watch your next few PSA scores. If it continues to rise then it may be time to switch to an other ADT drug, i.e. zytiga, casodex or xtandi.

Hotrod65 profile image
Hotrod65

Your still considered Undetectable from those numbers and many factors can contribute to small fluctuations in PSA as others mentioned, they usually look for a doubling of PSA over the course of 3 months before considered crPC and "T" level is equally important if it's on the rise.

j-o-h-n profile image
j-o-h-n

It was the sex orgy you attended before your test.....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 01/29/2020 7:31 PM EST

alephnull profile image
alephnull

And the answer is, the lab changed machines that read the PSA levels.

My new low is approx 0.17.

F'rs could have told me this at time of test, got to wait a month worried.

You may also like...

Have you any better ideas?

Beam Radiotherapy and ADT for 2 yrs. ADT on and off until 2 years ago. then PSA climbed...

High cost of Xtandi - any ideas?

advanced prostate cancer - at diagnosis he was 53 his PSA was 22 Gleason 4 + 3. His cancer is in...

Any thoughts on why PSA rising but mets status stable?

in 2010, after using ADT, Abiraterone, Olaprib, Provenge(Car-T) and now his PSA is about 5.2, with 5

225AC PSMA617 treatment any idea?

Any ideas for hot flashes? Getting worse.