Prazosin with Docetaxel?

[pjoshea13]

New Australian cell study below [1].

Looks like Prazosin may increase Docetaxel-induced toxicity.

"Some quinazoline-based alpha1-adrenoceptor (ADR) antagonists have previously been shown to have cytotoxic actions in PCa cells, but there is no research into their effects on docetaxel-induced toxicity."

"We hypothesised that prazosin, but not tamsulosin, in combination with docetaxel would possess synergistic cytotoxic actions on PC-3 and LNCaP PCa cells."

Both drugs have been used in the context of BPH:

Prazosin [2]:

"Prazosin is ... useful in treating urinary hesitancy associated with prostatic hyperplasia, blocking alpha-1 receptors, which control constriction of both the prostate and urethra."

Tamsulosin (Flomax) [3]:

"Tamsulosin, and other medications in the class called alpha blockers, work by relaxing bladder neck muscles and muscle fibers in the prostate itself and make it easier to urinate."

From the new paper:

"Prazosin sensitised both cell lines (PC-3 and LNCaP) to docetaxel-induced toxicity. This effect appears to be mediated by autophagy and may also involve apoptosis. These sensitising effects of prazosin appear to be largely independent of ROS production. In contrast, tamsulosin did not affect docetaxel-induced toxicity."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/296...

[2] en.wikipedia.org/wiki/Prazosin

[3] en.wikipedia.org/wiki/Tamsu...

[Chask]

Kangaroo meat is delicious. Very low fat and a little bit “gamey”. Sold widely in Australian supermarkets at around the same price as prime beef. Imagine it would be a lot more expensive in the US.

Would never have it au gratin - that sounds disgusting, but if you are happy to drink gator blood, well.........

[j-o-h-n]

I once ate Kangaroo meat... it was at a IHOP.

Good Luck and Good Health.

j-o-h-n Friday 04/20/2018 5:29 PM EDT

[ctarleton]

I had a hearty Kangaroo & noodle dish from the Adelaide Central Market once, and also a wonderful Kangaroo steak filet as part of a multi-course food/wine pairings dinner once in the Barossa Valley wine country of Australia. It tasted like a rich roast beef, taken up another couple of notches. Delicious. Thanks for stirring up that pleasant memory from a couple of decades ago.

Charles