On Lupron an xgeva , failed zytiga and now on xtandi 3 months psa has doubled every month it is up to 900 , but it’s weird it feel better

Losing hope

[Hidden]

Has anyone else had pain relief on xtandi but psa rapidly rising?

[charlesmeyers1964 in reply to Hidden]

i took it briefly but it didn't seem to relieve any of my pain because i had none.

charlie

[Kevinski65 in reply to Hidden]

I've been on Xtandi and Lupron. I'm 6 years out. 3 years on Lupron then Xtandi added after that. I'm having pain but PSA 0.02 for the past 3 years. I use aspirin. Bone scans, PET scans, and cat scan shows nothing significant. All 3 bone mets dormant, resolved whatever. I have pain at night in my femers, lower back and neck. It's probably micrometastasis, who knows.

[Fairwind]

You must get that explosive rise in your PSA under control...Have you done chemo ? Dosetaxel might be the ticket to slow things down and give you some time to develop a new treatment plan..

[Hidden in reply to Fairwind]

Not yet probably that’s next

[Tall_Allen]

Have you had Xofigo or Provenge?

[Hidden in reply to Tall_Allen]

Yes Provenge about a yr and a half ago

[Tall_Allen in reply to Hidden]

Talk to your oncologist about Xofigo if you have bone mets.

If visceral mets, consider the Lu-177-PSMA randomized clinical trial, now in Omaha, Indianapolis, Mayo Clinic, UCLA, Tulane, Albuquerque, Kettering OH, and Houston (there will be about 30 sites eventually):

clinicaltrials.gov/ct2/show...

[Hidden in reply to Tall_Allen]

Thanks I do have bone mets

[Hidden]

Thanks for you imput

[Fairwind]

The trial that TA mentioned is called "Vision" It's trial number is NCT03511664. They are doing this treatment in patients in Europe and Australia with good results..If you live near one of the locations doing the trial, it would be worth looking into..It's sponsored by a company called Endocyte

[charlesmeyers1964]

u didn't say what your psa is and how long have u had cancer. i've been fighting it now for 10 years. i just finished up a new tx since 2006 PROVENGE. check it out

charlie