Abiraterone plus PARP inhibitors after Taxotere- has anyone received health insurance approval?

[tallguy2]

I've just finished 6 rounds of chemotherapy (Taxotere). Next step per my MO and urologist is to start approx. 2 years of abiraterone (plus prednisone).

I learned from the recent summary of the June 2018 ASCO Annual Meeting that adding a PARP inhibitor (such as Lynparza, Zejula) to abiraterone can help stop genetic mutations that allow cancer cells to repair their DNA and keep living, and also improve a patient's ability to use additional drugs in the future, regardless of whether or not one has such DNA mutations to begin with. PARP inhibitors are supposedly being "fast tracked" for FDA approval but not yet FDA-approved for use with PCa. They are in Phase 3 clinical trials.

My question is: without FDA approval, has anyone had their MO or urologist successfully add a PARP inhibitor to Zytiga and have it covered by their insurance?

[Tall_Allen]

I've only heard of it used in a clinical trial, never by insurance.

[snoraste]

I've known people with BRCA2 mutations who have been taking it. My understanding was that for that specific mutation insurance subsidized the cost.

[tallguy2 in reply to snoraste]

Thanks for the info. I have been asking about Foundation One testing for that mutation...perhaps I will push a bit harder now.

[cbgjr in reply to tallguy2]

I'm on the same boat. I have the BRCA2 gene mutation.

Next week will be my 6th and last Taxotere infusion. And after that, My MO's plan is to start Zytiga + PARP inhibitor. He seemed to think there would not be a problem with insurance coverage (medicare + supplement)

[tallguy2 in reply to cbgjr]

I have been promised a call from my MO re: clinical trials involving PARP inhibitors + abiraterone. I'll post.

[Drcrunch in reply to cbgjr]

Have Brca 1 mutation and have been denied by my plan d carrier, aarp united healthcare. They said it is not approved. My dr. Is fighting it.

[Balsam01]

from what I understand, Johnson Hopkins is running trials where at least one arm of the trial gets that combo.