Anyone on PARP inhibitors?

[johngwilk]

I find out tomorrow whether I'll be entering a phase 2 clinical trial of a PARP inhibitor, niraparib (Zejula). I have a CDK12 DNA repair mutation that makes me a candidate for this intervention. (NCT02854436)

Looking for anyone who has experience with this or other PARP inhibitors re effectiveness and side effects.

TIA

[johngwilk]

Thanks. Hopefully one of the CDK12 cohort will answer back.

[vandy69]

Good Thursday Morning johngwilk,

I have been in this battle for almost six years (please see bio for complete treatment history).

After a Guardant360 liquid biopsy revealed an ATM defect, Dr. Snuffy Myers prescribed Lynparza, a PARP inhibitor.

It worked for me for 9 months with no side effects.

Best wishes. Never Give In.

Mark, Atlanta

[johngwilk in reply to vandy69]

Thank you.

[Cynthgob in reply to vandy69]

Why only 9 months? Or are you still on it?

[vandy69 in reply to Cynthgob]

After nine months, PSA started to rise again and Lynparza was no longer useful in my battle. Snuffy retired and I was on to other Med Oncs and treatments.

I had hoped for something more dramatic from Lynparza, but my cancer has been very aggressive since diagnosis in 8/12 and I am blessed to still be alive.

Best wishes. Never Give In.

Mark, Atlanta

[HopingForTheBest1]

I am considering adding a PARP inhibitor as an additional treatment option, as I am BRCA2 positive. Can you update me from your post from 9 months ago? Did you get in to the Niraparib trial? Were there any other PARPs available to you? How are you doing now?