Started Talazoparib this week. Anyone... - Advanced Prostate...

Advanced Prostate Cancer

23,340 members28,774 posts

Started Talazoparib this week. Anyone else?

7OaksTom profile image
6 Replies

My MO started me on Talazoparib (PARP inhibitor for ATM mutation) this week. Anyone else taking this this with Xtandi and 3 month Eligard shots.?

It has the normal scary list of SEs. What have been other's experiences?

Written by
7OaksTom profile image
7OaksTom
To view profiles and participate in discussions please or .
Read more about...
6 Replies
7OaksTom profile image
7OaksTom

Not on a clinical trial. Yes, I am taking the Talzenna formulation.

Tall_Allen profile image
Tall_Allen

Although it is approved for the ATM mutation, it really only works well for men who have the BRCA mutation. And it is very toxic:

prostatecancer.news/2019/10...

I suggest you enroll in the following clinical trial of a second generation PARP inhibitor. In early trials, it seems they may be beneficial against ATM+ and they are quite a bit less toxic. Module 5 accepts men in your category:

clinicaltrials.gov/study/NC...

7OaksTom profile image
7OaksTom in reply toTall_Allen

I stopped taking Talzenna because of the huge increase in fatigue. My MO agreed. QOL was more important than a 4 month lifespan improvement

Tall_Allen profile image
Tall_Allen in reply to7OaksTom

Maybe take a look at the clinical trial linked above for the 2nd generation PARP inhibitors- they claim fewer side effects.

7OaksTom profile image
7OaksTom in reply toTall_Allen

I just looked at this today and have sent AstraSeneca and email. Thanks Allen

Seasid profile image
Seasid

I believe their is a clinical trial for a new generation of Astra Zeneca parp inhibitors combined with darolutamide. Phase I first in humans to test for toxicity. This new parp inhibitor may have some effect on ATM mutation. Maybe you could contact Astra Zeneca for more information? The new parp inhibitors should be less toxic. Less negative effects on red blood cells.

Not what you're looking for?

You may also like...

started capazitaxel this week

went for my first treatment on Wednesday after seeing the scans of multiple spots in my liver and...
Muffin2019 profile image

Talazoparib with Xtandi

All, I’m starting talazoparib 0.5 mg this week in combo with Xtandi and Lupron. I’ve been on Lupron...
revchris77 profile image

Inquiry about Talazoparib (Talzenna) use

My MO is changing my off of Abiraterone to Xtandi and wants to add Talzenna to my regime. Reading...

Is anyone else doing this for their cancer?

Hello, this is my first posting on this website in February of 2017 at age 72, I was diagnosed...

Started Triplet Therapy this week, new doc, new (better) treatment plan!

Started triplet therapy this week with first dose of NUBEQA on Wednesday and Docetaxel yesterday...
Gl448 profile image

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.