ALP "bouncing" after starting Abiraterone (Zytiga)

I've experienced a bouncing upward of my Alkaline Phosphatase level after starting Zytiga, 5 weeks ago. My ALP jumped up to 111, just outside the normal upper limit. Apparently this is fairly common and along with a >50% reduction in PSA appear to be positive prognostic indicators.

Here's an article I found:

ncbi.nlm.nih.gov/pubmed/269...

[RustyDakota]

Mine certainly bounced when starting Zytiga. From 310 up to 705 within a couple weeks.

It has been slowly but steadily dropping since then. Now down to 61, eleven months later.

I don't know if the bounce did me any good, but I'm happy to see the decline.

[Hidden in reply to RustyDakota]

I suspect the mets are healing and the bone is remodeling. I didn't check my ALP until 5 weeks after starting Zytiga so it may be on the way down now. My PSA sure went down though, now it's 0.1, down from 26.5 at the last check 6 weeks ago.

[snoraste]

Same happened to me. It shot up after Zytiga and crashed back down. Who knows.

[Hidden in reply to snoraste]

According to what I've read, we are better off than those that have no "bounce" so I guess we should be happy. (smiley face indicates happy)

[erjlg3]

Sounds like a good sign Hope it gets better and better Gregg.

🙂Jackie

[leo2634]

My bounce concerned my Doctor so he put me on 750 mg. Zytiga dose instead of initial1000 mg. All blood work returned to normal in a few weeks that was six months ago and still normal today. PSA undetectable. The good thing about my Doctors instruction to cut down meds is two fold. One it worked, and two the cost reduced my copay .

[savingdaddy]

Hi Gregg, how are you? Just wondering if you ever tried Xtandi?

[Hidden in reply to savingdaddy]

I haven't tried Xtandi. I'm on Zytiga now, but when it stops working (hopefully a long time from now) I will probably try Xtandi. My last PSA check on Zytiga was undetectable and there are no side effects so I'm going continue with it.

[savingdaddy]

That is awesome Gregg! thank you for responding. Wishing you all the best. Keep being positive and keep fighting! God bless you

[Hidden]

Thanks!

[Mncwdj1]

my husband ALP was very high and the doc here in Edmonton, Alberta didn't say anything ... until suddenly he stopped the drug completely in December ...

what's the next step if ALP is very high actually ???

thanks