Response to Zytiga

[Blair77]

Can anyone point me towards stats on how many men respond to Zytiga once the PSA starts to rise on Lupron/ casodex? Also, how long the average response is?

Thanks ❤️🌈

[Tall_Allen]

Sure! Here's the data:

nejm.org/doi/full/10.1056/N...

[Blair77 in reply to Tall_Allen]

The link didn’t work ☹️

[Tall_Allen in reply to Blair77]

I edited it - try it now

[Blair77 in reply to Tall_Allen]

Thanks! It worked 👍🏻👍🏻

[Break60 in reply to Tall_Allen]

TA

What is meant by “ median not reached” in the Zytiga- prednisone arm?

[ctarleton in reply to Break60]

In the reference provided, Figure 1 Chart B shows the Zytiga-prednisone arm Overall Survival curve. "Median not reached" just means that greater than 50% of the men who started in that arm of the trial were still alive when the data were reported. The chart shows that the "curve" stops short of the 50% mark, as indicated by the scale on the left side of the chart, and the dotted line across the middle. (That was better, when compared to the Prednisone alone arm.)

[Tall_Allen in reply to Break60]

They did reach the 60% mark, however. Since the curved are still diverging, we can say with some assurance that In STAMPEDE, early Zytiga increased survival by at least 18 months; In LATITUDE, early Zytiga increased survival by at least 12 months.

[Blair77 in reply to Tall_Allen]

My husband has already done upfront Docetaxel so I’m not sure if these stats still apply?

[Tall_Allen in reply to Blair77]

Then these will apply:

ncbi.nlm.nih.gov/pmc/articl...

thelancet.com/journals/lano...