Best Place to Get Solid Tumor Genetic Testing for Prostate Cancer

[cesanon]

What is the best place to get solid tumor genetic testing for Prostate Cancer?

My understanding is that the leaders are: FoundationOne, Oncomine Dx, and Illumina

And that most hospitals save your original prostate biopsy for about 10 years... and all they need is the original biopsy slide. The tests are apparently covered by Medicare and most health plans. And once you get the Doctor's order, they take over and procure the specimen from the hospital for you.

So does anyone have any experience or knowledge about FoundationOne, Oncomine Dx, and Illumina Genomic testing labs?

[Hidden]

Thanks for the informative post.

[cesanon]

Nalakrats,

Do you know anything about Oncomine Dx:

thermofisher.com/us/en/home...

or

Illumina

illumina.com

[tango65]

Foundation one is very good.

[vandy69]

Good Monday Morning cesanon,

Over the almost 6 year course of my battle (please see bio), I have had 4 Guardant360 liquid biopsies and 1 FoundationOne biopsy.

Differences are evident in names--Guardant360 requires only 2 tubes of blood but FoundationOne requires actual tissue sample. I agree with earlier comment that using a 10 year old sample would yield results from the past, as your cancer has mutated since then.

I could see the genetic changes from the Guardant360 results--a later result indicated an ATM defect (not present earlier) and from that, Dr. Myers prescribed Lynparza, PARP inhibitor. Worked for about 9 months.

Best wishes. Never Give In.

Mark, Atlanta

[cesanon in reply to vandy69]

Thanks Mark

It does appear that FoundationOne has both a solid tissue and a blood-based test.

Sounds like the blood-based one may make the most sense, generally?

Is there any basis on which to compare and contrast the Guardant360 blood test to the Foundationone blood test? I think the FoundationOne blood test, tests for 360 genes?

How many genes did the Guardant360 test for? Is that something would be willing to double check?

[cesanon]

Hey everyone See this posting by Patrick:

Genomic Health, Inc. (NASDAQ: GHDX) today announced the U.S. commercial launch of the Oncotype DX® AR-V7 Nucleus Detect™ test. The first and only liquid biopsy test of its kind, the Oncotype DX AR-V7 Nucleus Detect test was developed by Epic Sciences to help prolong the lives of men with metastatic castration-resistant prostate cancer (mCRPC) by accurately detecting a splice variant of the androgen receptor protein (AR-V7) in the nucleus of circulating tumor cells (CTCs). Knowledge of a patient's AR-V7 status enables physicians to confidently decide whether men treated with an androgen receptor-signaling inhibitor (ARSI) therapy, such as enzalutamide and abiraterone, need to start another type of ARSI or switch to chemotherapy."

healthunlocked.com/advanced...

markets.businessinsider.com...

[cesanon]

JoelT,

Cancer ABCs has just arranged a partnering agreement with a company that will perform not only genetic sequencing of solid tumor tissue but also molecular and protein sequencing. They use the labs you listed as well as others depending on the tumor and cancer type. They will perform this service for all solid tumor types.....

See:

healthunlocked.com/cancer-t...

[BigRich]

What if the tissue sample is 15 years old, could not the cancer cells mutate in those 15 years? Therefore, wold not a new sample biopsy be needed?

Rich

[noirhole in reply to BigRich]

Yes I think that's correct. So would the insurance pay for that since a diagnosis has been made?

[BigRich in reply to noirhole]

The biopsy slide would be sent to the Lab for them to test against assay index. Medicare pays for some tests. However, this Wednesday the powers meet to decide how to curtail costs of these tests-- it is called cost containment.

Rich

[paige20180 in reply to BigRich]

Dear Rich, my husband just did a blood test through Biocept. It is inexpensive and they test for a lot of things. Our team at Mayo said to do a blood tests. They felt like my husbands RP slides 28 months old would be old news and the cancer has mutated by now.

[cesanon]

Thanks Nalakrats

[BigRich]

Thank you !

Rich

[Dan59]

IMO Tall Allen has the best comment, That being that over time Cancer can mutate, and that it would be more beneficial to have a current sample of the most mutated Cancer, I do not know where Mr. Allen came from, but his answers are always on point , and I am glad he is here. That said It is not always easy to get a sample surgically, as i know and spent a week in the Hospital after a robotic surgery to get a sample turned into full open and 8 days in the hospital a few years back. My question is are Blood samples for genetic testing as effective as getting a tumor sample?

Dan

[Hidden]

We got the original biopsy slides from my husband’s RP, which was done in 2003.

[Hidden]

Participating in the Metastatic Prostate Ca Project is very simple. I contacted them, husband received the kit and it was completed quickly.

[Tall_Allen in reply to Hidden]

That was really nice of you to contribute his data to their database. That will someday be a source of new personalized therapies.

[Hidden in reply to Tall_Allen]

Our son is 35. My husband has 8 nephews in their 30s. Our hope is that one day, they won't have to go through this.

[mlabrams54]

Filled out the questionnaire. Waiting to hear back.