Interesting reading regarding nadir and other things....
Be sure to click on the charts.
cancernetwork.com/oncology-...
I like this part, "1,395 patients enrolled in a prospective phase III study of intermittent vs continuous ADT in metastatic hormone-sensitive prostate cancer, a nadir PSA level < 0.2 ng/mL after 6 to 8 months of ADT was associated with a median overall survival (OS) of 75 months".
This is interesting reading for those who are considering early chemo treatment. It shows a far greater median survival rate.