How to determine a true and pristine psa doubling time and use it to manage therapy.

[rococo]

I am casodex 150 mg and avodart .5 mg and has been bouncing around between 3 and 5 for about a yr and a nurse told me about 5yr. doubling time. But now its been going up around .6 every month for the past 3 months. Psa is now 5,83. Had 3d conformal beam r.t. so i I still have a prostate and a high testosterone of 800. Wait another mo. Wanted exstandi next and my m.o doc. Said I can but with lupron which might not be a bad idea to crush it for another year.was even wishing psa rise might be just inflamation and go off everything to see..Afterall psa never went above 6 since and Iam 78yrs old . As usual the problem is What next. Thanks and cheers to all. Rocco

[PaulC2]

I'd be happy to calculate your PSA doubling time for you.

What is needed is a set of paired values:

(date1 : PSA1);

(date2 : PSA2);

(date3 : PSA3);

and so forth.

For example:

(13May2017 : PSA=5.83)

(11Apr2017 : PSA=5.26)

(14Mar2017 : PSA=4.64)

(12Feb2017 : PSA=4.31)

(10Jan2017 : PSA=4.24)

(09Dec2016 : PSA=4.31)

(14Nov2016 : PSA=4.19)

For best accuracy, provide exact dates; but if you don't have exact dates, a close approximation (e.g., "second week of March, or ?maybe? the third") is OK.

The more pairs of (date:PSA) values that you can supply, the more reliable the analysis.

[ctarleton]

Next time you talk to your Oncologist, you might ask about not just getting onto Lupron to get that high Testosterone down, but also the possible treatment Options that have come from the results of the CHAARTED and, just recently, the LATITUDE Clinical Trials.

ncbi.nlm.nih.gov/pmc/articl...

ascopost.com/News/55700

If possible, maybe send an email or letter ahead of time, so that there is time to review these things, and to be prepared to discuss them during your appointment. You want to know your Options, .... ALL your Options, and not just a Standard of Care that might be 5 years out of date.

Charles

[rococo in reply to ctarleton]

Thanks for info charles.. I was considering being more aggressive but cat and bone scan were neg.. Also had a glesson 6 or low 7 with psa 130 when . Tryed to be what was thought to be aggressive 17 yrs ago r.t ÷ adt 2. Than again with adt 3 with psa reccurrence. 3 yrs. After prim. therapy. Want to be sure before I commit this time since psa. has never whent above 6

[ctarleton]

To add to PaulC2's kind offer, there are also at least a couple of handy PSA Doubling Time Calculators available on-line, for Do-It-Yourself use, anytime.

mskcc.org/nomograms/prostat...

doubling-time.com/compute-P...

Charles

[rococo in reply to ctarleton]

Thanks to everyons but what I mean is most of us dont know our actual doubling as it is masked by meds.. or just coming off them. As in my case the casodex is losing its effect or the pc is becoming refractive? Need a clearer post on this.