Vitamin D3 prevents calcium-induced progression ...

[pjoshea13]

New study below.

"Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that faciliate progression to more aggressive stages is critical for disease prevention. Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impact on early-stage tumors remains unexplored. In this study, we addressed this issue with a large interventional animal study. Mouse models of fully penetrant and slowly-evolving prostate tumorigenesis showed that a high calcium diet dramatically accelerated the progression of prostate intraepithelial neoplasia, by promoting cell proliferation, micro-invasion, tissue inflammation and expression of acknowledged prostate cancer markers. Strikingly, dietary vitamin D prevented these calcium-triggered tumorigenic effects."

{Note. Calcium must be balanced by magnesium.}

-Patrick

ncbi.nlm.nih.gov/pubmed/278...

Cancer Res. 2016 Nov 22. pii: canres.0687.2016. [Epub ahead of print]

Vitamin D3 prevents calcium-induced progression of early-stage prostate tumors by counteracting TRPC6 and calcium sensing receptor upregulation.

Bernichtein S1, Pigat N1, Barry Delongchamps N1, Boutillon F1, Verkarre V2, Camparo P3, Reyes-Gomez E4, Méjean A5, Oudard SM6, Lepicard EM7, Viltard M7, Souberbielle JC8, Friedlander G9, Capiod T1, Goffin V10.

Author information

Abstract

Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that faciliate progression to more aggressive stages is critical for disease prevention. Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impact on early-stage tumors remains unexplored. In this study, we addressed this issue with a large interventional animal study. Mouse models of fully penetrant and slowly-evolving prostate tumorigenesis showed that a high calcium diet dramatically accelerated the progression of prostate intraepithelial neoplasia, by promoting cell proliferation, micro-invasion, tissue inflammation and expression of acknowledged prostate cancer markers. Strikingly, dietary vitamin D prevented these calcium-triggered tumorigenic effects. Expression profiling and in vitro mechanistic studies showed that stimulation of PC3 cells with extracellular Ca2+ resulted in an increase in cell proliferation rate, store-operated calcium entry (SOCE) amplitude, cationic channel TRPC6 and calcium sensing receptor (CaSR) expression. Notably, administration of the active vitamin D metabolite calcitriol reversed all these effects. Silencing CaSR or TRPC6 expression in calcium-stimulated PC3 cells decreased cell proliferation and SOCE. Overall, our results demonstrate the protective effects of vitamin D supplementation in blocking the progression of early-stage prostate lesions induced by a calcium-rich diet.

Copyright ©2016, American Association for Cancer Research.

PMID: 27879271 DOI: 10.1158/0008-5472.CAN-16-0687

[PubMed - as supplied by publisher]

[Dan59]

Patrick Thank You for your research

[Sisira]

Thank you Patrick for the useful post.

I eat lot of calcium rich small fish but at the same time maintain my Vitamin D3 ( cholecalciferol ) level too at an ideally high level. I test my blood regularly for Vitamin D3 ( Relatively expensive test ) because it is important in maintaining my bone health ( BMD ).

The relationship you have spoken of between the two show that I am safe to draw benefits from both.

Sisira

[Daddyishealing]

In studying calcium to MG ratio the former school of thought was always 2 to 1, but I read recently , I believe by Dr mercola that the ratio should be 1 to 1

does anyone know the correct ratio ?

[pjoshea13 in reply to Daddyishealing]

The 2:1 ratio was originally a suggested 'maximum' ratio, but somehow it became the 'optimum'.

Carolyn Dean has recommended: "going for a 1:2 or at the very least a 1:1 calcium-magnesium balance."

nutritionalmagnesium.org/op...

That's a radical change for those who have focused solely on calcium.

It would be interesting if there were to be an intervention study in men with PCa & confirmed magnesium intake insufficiency. The aim being to record before/after PSADTs. We are all looking for ways to extend the doubling time.

-Patrick

[Daddyishealing in reply to pjoshea13]

I agree Patrick . thank you for this post. I asked about MG because it seems magnesium is always the left out kid in American diets lol