Holy Atomic Pile Batman...Statins Can... - Advanced Prostate...
Holy Atomic Pile Batman...Statins Can make PCa Worse!
The Goldstein paper is 8 years old. It refers to a Tufts study by Alsheikh-Ali / Karas RH [1]:
"Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials."
Referring to the paper, Goldstein states:
"analysis of large randomized statin trials demonstrate a highly significant (p = 0.009) inverse association between achieved low-density lipoprotein cholesterol levels and cancer"
But later in 2008, Alsheikh-Ali / Karas RH released a follow-up [2]:
"Statins, Low-Density Lipoprotein Cholesterol, and Risk of Cancer"
"We recently reported an inverse association between on-treatment LDL-C levels and incident cancer in statin-treated patients enrolled in large randomized controlled trials, raising concern that LDL-C lowering by statins may increase cancer risk. However, meta-analyses suggest a neutral overall effect of statins on incident cancer."
"In the statin arms, meta-regression analysis demonstrated an inverse association between on-treatment LDL-C and incident cancer, with an excess of 2.2 (95% confidence interval: 0.7 to 3.6) cancers per 1,000 person-years for every 10 mg/dl decrement in on-treatment LDL-C (p = 0.006). The corresponding difference among control arms was 1.2 (95% confidence interval: −0.2 to 2.7, p = 0.09). Compared with the control arms, the statin regression line was significantly shifted leftward, such that similar rates of incident cancer were associated with lower on-treatment LDL-C (p < 0.05). Meta-regression demonstrated that statins lack an effect on cancer risk across all levels of on-treatment LDL-C."
"There is an inverse association between on-treatment LDL-C and incident cancer. However, statins, despite producing marked reductions in LDL-C, are not associated with an increased risk of cancer."
"The previously reported association of low levels of on-treatment LDL-C and incident cancer, confirmed here, is not driven by statins, and statin therapy, despite producing marked reductions in LDL-C, is not associated with an increased risk of cancer."
POW!
As I have mentioned, solid tumors accumulate cholesterol. Perhaps that has an effect on circulating levels? In any case, it seems that cancer itself is responsible for lower LDL-C.
-Patrick
Nal,
Forget about credentials...I would like to know about aging..PCa...and what can prevent PCa
Gus
Is Simvastatin more effective than the other statins, against PCa?
Can PCa spread from a bone met?
Statins reduce risk of developing PCa, as well as dying from it
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