Bicalutamide is supposed specifically to block metastatic cancer cells Testosterone receptors to starve them of their growth potential. Even so, testosterone has many additional functions, one of which is to produce and facilitate muscle growth and maintenance of the same. I have lost a lot of weight on my current ADT Biacalutamide regimen, 20 kg (about 45 lbs) in just about 3 1/2 months. I have asked my oncologist if there is any benefit to adding a SARM, like Enobosarm (Ostarine) or other, and am awaiting her response. I follow Keto, although not strictly, and train hard but am seriously afraid that I am loosing not only fat but muscle mass. Hence my question!. Anyone had similar thoughts or experiences from SARMs in conjunction with Bicalutamide?
Bicalutamide and the way of Testosteron - Advanced Prostate...
Bicalutamide and the way of Testosteron
Are you exclusively on Bicalutamide, because the term ADT is used to denote Luprolide. If yes, you may try the Minimum Effective Dosage instead of the standard 50 mg/day or 150 mg/day in some countries for monotherapy. I have been on 1/10 (25 mg/5days) the standard dose for 3 years without loosing any weight, which I would have liked.
Many thanks for dropping these lines Justfor_. From my horizon ADT encompasses quite a few substances used for Androgene Deprivation Therapy. That set aside, Yes I am on my third Bicalutamide treatment and responding fairly well so far but have lost a lot of weight during a short period. A little bit scared of loosing muscle mass as I am not an any way obese. Your Minimum approach to SARM regime looks very interesting and just wonder if it is Osterine?
No SARMs for me. What I do and take is documented here:
I have been on SARM's for 2+ years now(Osterine) with approval of my MO. gained considerable amount of muscle over that time. 185lbs without SARM"s looks horrible compared to me at 195lbs on SARM's. When administered properly, paired with a good workout and diet, muscle growth is very possible. I began to see results at about 6 week mark.
Thanks mrscruffy. Valuable points especially when you had the approval of your MO. Went from about 175 lbs after radiation in 2021 to 195 lbs in a few months. Now on Keto, Training and Bica and lost about 44 lbs (weight now more or less 150 lbs) since the beginning of July. Are you currently on any other medication specifically for PC/MPC? If so, your MO mentioned something about doing Bica and Osterine at the same time?
I did Lupron/Zytiga for 8+ years until it failed, I am now on Lynparza. I cyle the Ostarine every 6 weeks to prevent any kind of problems. Oddly enough Ostarine was designed for Prostate cancer and gave me an extra year when ADT started to fail. At least that is what MO believes.
You wouldn't use both. Bicalutamide blocks androgen receptors on all cells (PCa, muscle, etc.), so there is no point in using it together with a SARM.
Without going into any polemics here on the forum is there any, to your knowledge, publication made on this topic? No matter if it´s Bicalutamide or any ADT that have been simultaneusly administrated?
It would never be tried because its counterproductive to combine them. Trials have to make sense. There have been trials of SARMs alone in men who have already had curative therapy.
That is really the issue. I understand that SARM stands for selective modulator of androgen receptors, but is it really true that Bicalutamide has the same effect on all cells receptors? As Testosteron has so many versatile functions I think that the question is legitimate even though as you say it doesn´t make sense, still no simultaneous trials.
People who understand biochemistry would not be interested. Bicalutamide prevents activation of the androgen receptor on all cells. You might want to read a textbook on biochemistry.
I am a Biologist
You may want to review some basic texts, then.
Nothing is only black or white. It´s like saying cancer can only be explained to be a thing derived from mutations which we now had as pardigm for at least 50 years. How can anyone cathegorically say that because "basic texts" say something this has to be 100% true?
You obviously don't understand how the AR works, what anti-androgens do, and its ubiquity.
I think noone does in full
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