Prostate cancer goes from being a chronic disease that can be controlled with ADT to a a fatal disease when it changes to CRPC. Is there a combination of supplements and drugs that can block the pathway the cancer uses to become CRPC. My bet is there is and so far I have come across 5 cases of PCa G 7 (4+3) or higher where the men have been on IADT for 7 years or longer. In all cases they were taking pomegranite, lycopene, curcumin, resveratrol, zinc, boron, and metformin as part of their supplement regimen in addition to IADT. Anyone have success with any other supplements.