Advanced Prostate Cancer
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In yesterday's thread on "Jevtana and Prednisone", no mention was made of the potential effect of prednisone on the cancer. In fact, Eric wrote that: "prednisone in itself does nothing to stop or slow the cancer".

In fact, there may be add-on value in the combined treatments where prednisone is included for other reasons.

From the bad old days:

1] 1998 - Effect of predisone on PSA in CRPC. "10 mg of prednisone orally two times a day."

"The mean and median PSA decline after initiating prednisone was 33%"

"Ten patients (34%) had a PSA decline of more than 50% and 4 patients (14%) had PSA declines of more than 75%."

2] 2001 - Flutamide versus prednisone in CRPC.

"In symptomatic HRPC, treatment with prednisone or flutamide leads to similar rates of {time to progression} and overall survival and no difference in subjective or biochemical response. The QL results favor the use of low-cost prednisone in patients with HRPC."




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When I took my chemo trial twelve years ago part of the regime was 30 mg of Prednisone each day for six months (10 mg and 20 mg twice a day). I asked Dr. Amato why. His response was simple, "My research show that Prednisone has prostate cancer killing properties."

Keep Kicking the Bastard,



So sorry.......I can't keep up. Is prednisone good or bad when you have cancer?


I doubt that many men are happy about taking a drug that is an immunosuppresant, but there appears to be an independent benefit when used against PCa.

By independent, I mean that prednisone alone might have some benefit.

I have written many posts about the importance of controlling inflammation. PCa is certainly an inflammatory disease. Eliminate the inflammation & the PSA doubling time might increase. Prednisone is used to treat certain inflammatory diseases, although one doesn't need prednisone to address inflammation.

It does have a downside. Blood glucose goes up. I think it very important with PCa to restore insulin sensitivity, & this would be difficult to do while taking prednisone. There are other side effects too.

While using a treatment drug where prednisone is part of the treatment, one can take solace in the fact that prednisone is adding value (IMO).


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