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The steroid with zytiga can be a deal
(He's also on
flutamide
? I think). I have since found quite a bit of supporting research so just wanted to share.
(He's also on
flutamide
? I think). I have since found quite a bit of supporting research so just wanted to share.
TomsD1
in
Advanced Prostate Cancer
5 days ago
Antiandrogen Withdrawal Syndrome After Stopping Enzalutamide in Metastatic Castration-Resistant Prostate Cancer: Two Case Reports & Review
This was initially described for older agents, such as
flutamide
, bicalutamide, and nilutamide; moreover, before the approval of enzalutamide and abiraterone, this phenomenon could be used to postpone the beginning of chemotherapy in mCRPC [7]. AAWS after enzalutamide is not well established.
This was initially described for older agents, such as
flutamide
, bicalutamide, and nilutamide; moreover, before the approval of enzalutamide and abiraterone, this phenomenon could be used to postpone the beginning of chemotherapy in mCRPC [7]. AAWS after enzalutamide is not well established.
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Eligard for me= poison
Doctor Larock from Mattapoisett is treating me with
Flutamide
and Bicalutimide 1 pill day each. Thanks Jesus I can write this and feel pretty good for 75. Eligard & myself= disaster.
Doctor Larock from Mattapoisett is treating me with
Flutamide
and Bicalutimide 1 pill day each. Thanks Jesus I can write this and feel pretty good for 75. Eligard & myself= disaster.
Shorttimer
in
Advanced Prostate Cancer
1 year ago
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Will Androgen-nourished Prostate Cancer Cells Succumb to "Glucose/Glutamine Starvation"?
If prostate cancer cells are enriched with androgens that normally propel their growth and spread, could they still be "starved" by selectively inhibiting their GLUT receptor expressions to block their uptake of glucose and also by limiting their ability to turn to and utilize glutamine as a backup
If prostate cancer cells are enriched with androgens that normally propel their growth and spread, could they still be "starved" by selectively inhibiting their GLUT receptor expressions to block their uptake of glucose and also by limiting their ability to turn to and utilize glutamine as a backup
back2health
in
Advanced Prostate Cancer
3 months ago
Almost ready for phase 1: JHU083 (or JHU-083) a selective glutamine metabolism blocker
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
Maxone73
in
Advanced Prostate Cancer
3 months ago
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Zinc L- Carnisone with L- Glutamine
Hi everyone, have any of you tried the above marketed as THERA NORDIC REZCUE. It is supposed to be benificial in healing inflammation in the digestive tract. Your comments would be welcome , thanks
Hi everyone, have any of you tried the above marketed as THERA NORDIC REZCUE. It is supposed to be benificial in healing inflammation in the digestive tract. Your comments would be welcome , thanks
Helliborous
in
Pernicious Anaemia Society
5 months ago
Bloating
Hi....I've battled with IBS for many years and following endoscopy and gastroscopy I was diagnosed with a lazy stomach. Dietary controls and careful eating seemed to keep things under control with minimal 'episodes' of wind, bloating and diarrhea. Fast forward a few years and following a prolonged course
Hi....I've battled with IBS for many years and following endoscopy and gastroscopy I was diagnosed with a lazy stomach. Dietary controls and careful eating seemed to keep things under control with minimal 'episodes' of wind, bloating and diarrhea. Fast forward a few years and following a prolonged course
Sardinesagain
in
IBS Network
6 months ago
L Glutamine
Hi everyone, could anyone advice me on L Glutamine, I have Intestinal Metaplasia and I don't know if I should take it. I have read it supports the stomach lining but I am concerned that this would only help a 'normal stomach' and I may do more harm than good. Thanks
Hi everyone, could anyone advice me on L Glutamine, I have Intestinal Metaplasia and I don't know if I should take it. I have read it supports the stomach lining but I am concerned that this would only help a 'normal stomach' and I may do more harm than good. Thanks
Helliborous
in
Pernicious Anaemia Society
6 months ago
Enzalutamide & 5-year survival in mHSPC.
"Patients in the ENZAMET trial (n = 1125) were randomized 1:1 to arm A, the control arm consisting of TS plus a standard non-steroidal antiandrogen ([NSAA] bicalutamide, nilutamide, or
flutamide
), or enzalutamide at 160 mg per day plus TS in arm B. " "The 5-year OS rates were 81% and 66% for those with
"Patients in the ENZAMET trial (n = 1125) were randomized 1:1 to arm A, the control arm consisting of TS plus a standard non-steroidal antiandrogen ([NSAA] bicalutamide, nilutamide, or
flutamide
), or enzalutamide at 160 mg per day plus TS in arm B. " "The 5-year OS rates were 81% and 66% for those with
pca2004
in
Fight Prostate Cancer
1 year ago
Are Functional Motor Symptoms Influenced by Glutamate and Glutamine Fluctuations?
I was reading an old post and someone commented about this, so naturally I asked the question and found this study: https://www.neurologylive.com/view/functional-motor-symptoms-influenced-glutamate-glutamine-fluctuations Interesting reading and saying that the "functional movements" are down to biology
I was reading an old post and someone commented about this, so naturally I asked the question and found this study: https://www.neurologylive.com/view/functional-motor-symptoms-influenced-glutamate-glutamine-fluctuations Interesting reading and saying that the "functional movements" are down to biology
Lady4
in
Functional Neurological Disorder - FND Hope
7 months ago
Supplement Guidance
Hello all So after years of a tummy that reacted to certain foods, being diagnosed as gluten intolerant in 2016, really suffering in 2021 and 2022, following a FODMAP diet recommended by my doctor (don’t recommend) and getting to a point where I only ate the same plain things everyday, I finally paid
Hello all So after years of a tummy that reacted to certain foods, being diagnosed as gluten intolerant in 2016, really suffering in 2021 and 2022, following a FODMAP diet recommended by my doctor (don’t recommend) and getting to a point where I only ate the same plain things everyday, I finally paid
Kimsy17
in
IBS Network
9 months ago
L glutamine benefits ?
Hi everyone, I am thinking of ordering some of above but not sure if taking it is safe as I have AMAG with neuroendocrine hyperplasia can anyone offer any advice please.
Hi everyone, I am thinking of ordering some of above but not sure if taking it is safe as I have AMAG with neuroendocrine hyperplasia can anyone offer any advice please.
Helliborous
in
Pernicious Anaemia Society
9 months ago
Glutamine
Hey, has anyone any experience using glutamine for Atrophic Gastritis
Hey, has anyone any experience using glutamine for Atrophic Gastritis
Helliborous
in
Pernicious Anaemia Society
9 months ago
confused about supplements and certain foods
greetings I’m trying to get some clarity on what I can eat and take as supplements. My PSA is currently undetectable but clearly with ADT I’m trying to build or keep as much muscle as possible. I take creatine would like to add bcaa/lucene and glutamine. Any issues here? Also I tend to consume a
greetings I’m trying to get some clarity on what I can eat and take as supplements. My PSA is currently undetectable but clearly with ADT I’m trying to build or keep as much muscle as possible. I take creatine would like to add bcaa/lucene and glutamine. Any issues here? Also I tend to consume a
SierraSix
in
Advanced Prostate Cancer
11 months ago
Final STAMPEDE results for Abi with/out Enza when starting ADT.
In terms of AR inhibition, Enzalutamide [Enza] was more effective than any of the "lutamides" that began with
Flutamide
[1989]. One could hardly therefore expect much incremental benefit in combining Abi & Enza.
In terms of AR inhibition, Enzalutamide [Enza] was more effective than any of the "lutamides" that began with
Flutamide
[1989]. One could hardly therefore expect much incremental benefit in combining Abi & Enza.
pca2004
in
Fight Prostate Cancer
1 year ago
More on abiraterone prices
I know that there have been many posts on this subject. But because this affects many of us, I hope you can indulge me one more post. My basic question is: Have some of you stopped buying abiraterone (generic Zytiga) through your Medicare Part D insurance provider and started buying abiraterone through
I know that there have been many posts on this subject. But because this affects many of us, I hope you can indulge me one more post. My basic question is: Have some of you stopped buying abiraterone (generic Zytiga) through your Medicare Part D insurance provider and started buying abiraterone through
Gearhead
in
Advanced Prostate Cancer
1 year ago
RLS amino acids
Hi, I don't have RLS since taking Amino Acids. If I leave them off 2 nights running it comes back as bad as before. I don't know if they do me any harm but it's better than the torture every night. I take Glutamine, Ornithine and Lyseine. If anyone tries this please let me know how it goes. I have
Hi, I don't have RLS since taking Amino Acids. If I leave them off 2 nights running it comes back as bad as before. I don't know if they do me any harm but it's better than the torture every night. I take Glutamine, Ornithine and Lyseine. If anyone tries this please let me know how it goes. I have
1jeremiah1
in
Restless Legs Syndrome
1 year ago
Glutamine and RLS Does anyone have any info please?
Hi! Please help if you can. I just finished breast cancer chemo and have now developed peripheral neuropathy despite wearing ice on my hands and feet for two hours during treatment. My RLS was finally pretty under control because I went on Trazadone 50 mg. Still taking. .25 Mirapex and Lunesta. Now
Hi! Please help if you can. I just finished breast cancer chemo and have now developed peripheral neuropathy despite wearing ice on my hands and feet for two hours during treatment. My RLS was finally pretty under control because I went on Trazadone 50 mg. Still taking. .25 Mirapex and Lunesta. Now
charlottesgrandmom
in
Restless Legs Syndrome
1 year ago
Targeting Glutamine Metabolism
New paper below [1a]. Full text: [1b]. First, a few notes. "Studies have indicated the importance of glutamine in certain tumors. For example, the inhibition of glutamine metabolism was reported to prevent growth of several tumors such as breast, liver, kidney and T-cell lymphoblastic leukemia." Wiki
New paper below [1a]. Full text: [1b]. First, a few notes. "Studies have indicated the importance of glutamine in certain tumors. For example, the inhibition of glutamine metabolism was reported to prevent growth of several tumors such as breast, liver, kidney and T-cell lymphoblastic leukemia." Wiki
pjoshea13
in
Fight Prostate Cancer
1 year ago
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