Rise in PSA

[ironmanburg]

Hello everyone, I am 72 and have been on active surveillance for prostate cancer since I was diagnosed in August 2021 but probably had it prior to my first MRI in 2020. I have had 2 biopsies and 5 MRI's and countless PSA tests. The first bx showed 3 cores at 3+3 and 2 cores suspicious, confirmatory bx a year later showed 1 core at 3+3 and 1 core suspicious. My PSA has risen from 3.9 in 2018 to 12.7 and back to 11 this year. My previous MRI's showed a bladder outlet obstruction and BPH and one probable subcentimeter utricle cyst rated Pirads 2, the latest MRI report showed the probable subcentimeter utricle cyst as Pirads 3 (grew a bit) and didn't say anything about the bladder outlet obstruction or BPH. All surrounding areas were fine. When I saw my Urologist I brought this up and he had no answer for me other than to say I moved up to an intermediate unfavorable risk since my PSA was up. Said the size of my prostate was borderline enlarged anyway. I suggested that maybe riding my bike 5000 miles a year for over 20 years may have something to do with my rising PSA since the prostate may be in a constant state of proctitis and he had no answer. Of course, he suggested a prostatectomy which I am not going to do at this point. I have no other symptoms, I train and compete in Ironman triathlons, eat a Vegan diet, and get plenty of rest/sleep. My question is, has anyone else had a similar journey and where did you end up? Since this post, I have moved my care to Dr. Michael Poch at Moffitt Cancer in Tampa. I saw him on Monday and all signs point to me remaining on active surveillance and to have a PSA test that day and again in 6 months for a follow-up visit. My concern is that my PSA was 21,38 at the new testing site, up 10 points from 3 months ago. I just wanted to know if anyone else has experienced this after testing at a new lab? Thanks.

[Drianbrain]

Hi, I've been told by my urologist not to compare PSA tests from different labs. I had a PSA on 7/4 done by Quest =1.93 and one at the local hospital on 7/23, =2.90. The ones at Quest are always lower. But I'd ask your new urologist. Best Regards.

[ironmanburg in reply to Drianbrain]

Thanks. I did have a severe case of bronchitis and just finished up a round od antibiotics so maybe that had something to do with it. I guess the urologist wasn’t alarmed enough to call me.

[aceace12]

odd that its went up that high ....please get it checked out .. i am similar to all of you diagnosis and test results.. but my PSA has always been 4.0 or below