If you are positive for C-ANCA, is it the same thing as being PR3 positive? And does the titre number mean anything about disease activity ?eg. high titre, more ill;; low titre, less ill?
In your experiences, what is the best treatment for skin manifestations?
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Christophene47
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cANCA and anti PR3 are the same and are usually associated with GPA ( WG ). High titre doe suggest a higher level of disease activity but it is not a wholly reliable guide. Skin manifestions are just a sign of the underlying disease so the answer is to treat the underlying disease not mess about treating the skin.
Thanks, John. I have been confused about this because one rheumatologist diagnosed GPA with a PR3 titre of 1.6. A second opinion from a vasculitis specialist thought I was "on a continuum of an inflammatory arthritis; wasn't ready to confirm GPA with a. weak titre "at this time" is how she put it, It was 1.1 by the time I could get an appointment with her after 6 months on prednisone. She also "discounted " a granuloma annulare." I had a biopsy of from my hand.
I was tapering prednisone per her suggestion and down to 8mg from 16mg when I lost vision for a few minutes in 1 eye. . Results pending on duplex doppler of carotid s and orbits. ordered by neuroophthalmologist.
Original rheumatologist put me on 1x week Methotrexate and keeping me at 8mg prednisone, and sent me to hematology for high white count which I assume is from prednisone. Guess defensive medicine!? The hematologist ordered a repeat CBC and a blood flow oximeter test; results pending.
I imagine these drugs should be treating the skin, but so far not too well. On Methotrexate 5 or 6 weeks now.
There also seems to be different techniques used by different labs, and therefore different parameters. As you know, all very confusing after 18 months. Still not feeling "normal."
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