Titre levels

[Jase222]

Hi, I have MPA and just have had anca blood test come back ! It says a titre level of 1:80 ? Does anyone know what this means and and what are average levels

Thanks

[AndrewT]

Dear Jase222,

Actually, no don't know either, in fact I have never heard of ''Titre levels' before. I do know about Creatinine levels, with regards to Kidneys, and 'markers', for ANCA/Non-ANCA Vasculitis. I have also 'heard of' various other Markers/Indicators, too numerous to mention in detail.....but NOT this one. Sorry that this is NO help, at all-is it?

Sorry I can't be more help Jase.

Kind regards anyway.

AndrewT

[Chris-Bromsgrove]

Hi Jase222, I also have MPA and I have heard my consultant refer to titre when discussing ANCA level, however I am not sure what it means. All I do know is there are two types of ANCA (PR3 antibody which is c-ANCA and MPO antibody which is p-ANCA). So the the reading is usually goes along the lines ANCA PR3 80. I have the PR3 antibody but I believe the MPO is more common with MPA vasculitis. I have never seen the ANCA level expressed as a ratio (1:80). If it means your ANCA level is 80 that would seem to be rather high if you are in remission but the main thing to be concerned about is if the ANCA reading has shot up from a lower level. Probably best to have a word with your doctor if you are unsure.

Chris

[tamidi in reply to Chris-Bromsgrove]

Hi

My doughter have MPA since 2012.

She has Anca 1:80

I think that is normal 1:20.

Anca couse bleeding in lung and in kidnay in her case.

I'm sorry because my English is not good.

[tamidi]

If an ANCA test result is positive, then an additional test is performed to determine the amount of antibody present. This is called a titer. To determine the titer, a serum sample is diluted in steps and each dilution is tested for the presence of the antibody. The greatest dilution at which the antibody can be detected is the titer. For example, if a serum tests positive after being diluted 64-fold, the titer is 1:64. The higher the titer, the more antibody is present in the blood.

[Chris-Bromsgrove in reply to tamidi]

Thanks for that information Tamidi. That explains titre. The word must have its derivation in titration which I vaguely remember something about in O level chemistry. Chris

[Hidden in reply to tamidi]

Excellent explanation. My doctor also explained that the titer steps are based on the next level of dilution, which means they double the longer the antibodies can be detected in even greater dilutions: 1:64 is followed by 1:128 by 1: 256 etc.

So the higher the second figure, the greater the presence of ANCA.