What is the comparative degree of "suppression" of an immune system when treated by the following drugs at different dosages and combinations?
1) Mycophenolate (2,000mg)
2) Prednisolone (60mg)
3) Prednisolone (10mg)
4) Prednisolone (60mg) + Mycophenolate (2,000mg)
Neil PerryMy background and medical status:-
Diagnosed with Churg Strauss Syndrome on 22 April, 4.5 months ago, not reached remission yet.
- Prednisolone start at 30 and Mycophenolate at 2,000
- Also on Hydrocortisone 25 for Addison's Disease, equiv to 25/6.5 of Prednisolone = 4
- So TOTAL steroid was (30 + 4) 34
Early last week, got hit Tue night by first infection so far with severe stabbing back chest pain, but no other symptoms. 999 -> A&E.
CRP inflammation marker went up to max of 250mg/L (that is very high!), in hospital for 6 days on IV antibiotics. Drug levels during this episode ....
1) Initial Medication
- Pred at 30, Hydrocort 25 and Mycophen at 2,000
- so Total steroid (30 + 4) = 34
2) Prior to Infection
- Pred at 12, Hydrocort 25 and Mycophen at 2,000
- so Total steroid (12 + 4) = 16
3) In hospital
- Pred at 20, Hydrocort 50 and Mycophen at Zero
- so Total steroid (20 + 8) = 28
- plus IV antibiotics
3) At home now
- Pred at 15, Hydrocort 25 and Mycophen at Zero
- so Total steroid (15 + 4) = 19
Current status: Awaiting today's CRP test result for decision on when to restart of Mycophenolate.
Remember the ORIGINAL question:
"What is the comparative degree of "suppression" of an immune system when treated by different drugs at different dosages?"