Has anyone experienced peripheral neuropathy with thyroid issues? From around 14 years old (I am now 44) I developed an intense tingling which would start from my chest and move upwards. Shortly after my thyroidectomy I began taking a small dose (10mg) of Amitriptyline which does ease the symptoms. However, after reading about the connection between hormone issues (stress levels) and cell inflammation I have decided to go down the nutrition route to try and regenerate my cells. I had weaned off the Amitriptyline over the last few weeks but last night the symptoms are returning, especially an intense coldness in my right foot/lower leg (different to the usual cold hands and feet with hypo) and I had tingling in my face/mouth and a burning sensation in my mouth.