I have been wondering this for some time and can't find an answer. Mine was dead (well just about) when first diagnosed 3 years ago with a barely detectable T4 and TSH60. My meds since then have been up to 1oomcg thyroxine and down to 75 then back up and I'm now on 75mcg and still have a TSH of under 1. Could this indicate that it has started working a bit on its own? I know you never "get better" but it would make me feel a lot happier to think there was some natural activity. Thank you.