Just checking whether I need to investigate - Thyroid UK

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Just checking whether I need to investigate

OneBrainCell profile image
18 Replies

Hi,

57 year old guy, increasing fatigue, enthusiasm, libido, etc.

Was thinking that symptoms were signs of low testosterone so have gone for blood tests.

Testosterone ok "for my age" (though the %ge free is very low) but somebody pointed out that my T4 was very low though just in range.

And many of the symptoms I'm experiencing could I guess be thyroid related.

So I'm really just asking if anyone here thinks these figures are concerning and should I investigate further with for example a full thyroid blood panel.

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OneBrainCell profile image
OneBrainCell
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18 Replies
Obsdian profile image
Obsdian

Your t4 is in range but too low. Chances are your t3 is also too low and causing your issues. It would be helpful to also test your t3.

DippyDame profile image
DippyDame

No FT3....essential!

For good health every cell in the body ( millions) must be flooded with T3 by way of an adequate and constant supply

Low cellular T3 = health problems

Being in range is not good enough, you need to find the point within the range where you feel well and symptom free.

We aim for Frees to be roughly approaching 75% through the ref range

Quick calculator.

thyroid.dopiaza.org/?utm_so...

Your FT4 at 12.00 (12 - 22) is 0%....

Your FT4 is clearly abysmally low. You need a full thyroid panel

Symptoms of hypothyroidism here

thyroiduk.org/signs-and-sym...

I don't know enough about the other tests but I do know that your FT4 points to the need for further testing....asap

Vit D, vit B12, folate and ferritin must all be optimal to support thyroid function..

And if not already tested then check thyroid antibodies TPO and Tg.

Raised levels indicate Thyroid Autoimmune disease/ Hashimotoes, a common cause of hypothyroidism

I would be confident that your symptoms are caused by hypothyroidism.....the results of a full thyroid test will point to the cause and to the treatment required

thyroiduk.org/testing/

Normal starting dose is 50mcg followed by another test in 6/8 weeks. Repeat increse, wait, test until symptoms resolve and numbers improve.

bmcendocrdisord.biomedcentr...

Time for a reassessment of the treatment of hypothyroidism

John E. M. Midgley, Anthony D. Toft, Rolf Larisch, Johannes W. Dietrich & Rudolf Hoermann

Testing protocol ...

Test at 9am on an empty stomach....water allowed!

If medicated....

Test 24 hrs after last dose of levothyroxine and 12 hrs after T3

Post the results for advice.

We're all here to help....just ask.

Good luck

SlowDragon profile image
SlowDragonAdministrator

Suggest you get FULL thyroid and vitamin testing

what vitamin supplements are you taking……if any?

Ft4 is low

Could be low vitamin levels and/or thyroid

For full Thyroid evaluation you need TSH, FT4 and FT3 tested

Also both TPO and TG thyroid antibodies tested at least once to see if your hypothyroidism is autoimmune

Very important to test vitamin D, folate, ferritin and B12 at least once year minimum

Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease

About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high TPO and/or high TG thyroid antibodies

Autoimmune thyroid disease with goitre is Hashimoto’s

Autoimmune thyroid disease without goitre is Ord’s thyroiditis.

Both are autoimmune and generally called Hashimoto’s.

Significant minority of Hashimoto’s patients only have high TG antibodies (thyroglobulin)

NHS only tests TG antibodies if TPO are high

20% of autoimmune thyroid patients never have high thyroid antibodies and ultrasound scan of thyroid can get diagnosis

In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)

ALWAYS test early morning, ideally just before 9am, only drink water between waking and test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

Post all about what time of day to test

healthunlocked.com/thyroidu...

Testing options and includes money off codes for private testing

thyroiduk.org/testing/

Medichecks Thyroid plus BOTH TPO and TG antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes BOTH TPO and TG antibodies, cortisol and vitamins

bluehorizonbloodtests.co.uk...

Medichecks and BH also offer private blood draw at clinic near you, or private nurse to your own home…..for an extra fee

Only do private testing early Monday or Tuesday morning.

Tips on how to do DIY finger prick test

support.medichecks.com/hc/e...

OneBrainCell profile image
OneBrainCell in reply toSlowDragon

Vitamin D and ferratin are both ok - recent blood tests.

I take vitamin D, zinc and a good multivitamin supplement daily.

I think I'll get a full test done anyway just for peace of mind - it's money well spent even if I (hopefully) find out there's not a major issue.

Are the finger-prick tests good enough or is a blood draw significantly better?

Hedgeree profile image
Hedgeree

Welcome to the forum OneBrainCell,

You've had some great responses so far.

There's many experienced members on this forum with much personal experience in thyroid issues so you're in a good place here. 😊

Don't think anyone's asked yet but what's your diet like? Do you eat from all food groups? Or are you vegetarian?

OneBrainCell profile image
OneBrainCell in reply toHedgeree

Thank you 😊

Eat from all food groups. Try to eat clean and avoid as much UPF as possible, etc... but I'd be lying if I said my diet was perfect.

No alcohol for well over a year.

greygoose profile image
greygoose

Hi OneBrainCell, welcome to the forum. :)

Vitamin D and ferratin are both ok - recent blood tests.

What do you mean by 'ok'? Do you have the exact numbers - results and ranges?

I take vitamin D, zinc and a good multivitamin supplement daily.

Are you also taking the cofactors of vit D? Vit K2-MK7 and magnesium? Your vit D level could be brilliant but if you haven't got the magnesium to go with it- and most people don't - it's not going to do much for you because your body won't be able to use it.

Also, taking vit D increases absorption of calcium from food, so the vit K is necessary to make sure that extra calcium goes into the teeth and bones, and doesn't build up in the soft tissues and arteries.

Did you get your zinc and copper tested before supplementing zinc? They need to be kept balanced, but if you are hypo - and it rather looks as if you might be - you will probably have either zinc or copper too low, and therefore the other one too high. You need to know if this is the case.

There's no such thing as a 'good' multi-vit. Doesn't matter how much you pay for it, the whole concept of a multi-vit is wrong. There are many, many reasons why they're a waste of money but the main reason is: if they contain iron, you won't absorb much of the other ingredients because the iron will block them. That's what iron does.

Also, they contain things you just don't need and which can be harmful in excess. Calcium, for example. Highly unlikely you need it. And iodine, which is anti-thyroid in excess and not something a hypo should be taking.

What time of day was the blood draw for the above test? That's important to know because TSH - which is all most doctors look at - varies throughout the day and is highest before 9 am. It's lowest around midday. And your TSH is low considering how low your FT4 is. They don't balance.

OneBrainCell profile image
OneBrainCell in reply togreygoose

Thanks 🙂

Vitamin D was 62 nmol/L so NHS advice was no repeat measurement taken, standard dose (10mcg) ED advised.

I take a 100mcg supplement daily.

The Ferratin was 222 ug/L (range 30 -400)

I take 1500mg magnesium glycinate nightly for sleep.

I currently supplement zinc as am using a daily injection of GHK-CU.

Blood draw was done at 0900 fasted.

Good shout on the vitamin K / calcium - that's something I'll look into. Aware of the issues of multivits and should/will probably use less often.

greygoose profile image
greygoose in reply toOneBrainCell

So why are you injecting copper? When did you last have them both tested?

Drop that multi in the dustbin, where it belongs! Highly unlikely it will be doing you any good and could be doing you harm.

Was CRP tested at the same time as your ferritin?

OneBrainCell profile image
OneBrainCell in reply togreygoose

Injecting copper as part of the Glow protocol.

CRP not tested.

greygoose profile image
greygoose in reply toOneBrainCell

I've never heard of the Glow Protocol. Is this it:

london-regenerative.com/aes...

I would be very, very wary of something that involves injecting copper every day! Over-dosing on copper is no fun! Did you have both copper and zinc tested before starting this protocol?

Important to test CRP at the same time as ferritin because it's an inflammation marker. High levels of inflammation can cause false 'high' ferritin levels.

OneBrainCell profile image
OneBrainCell in reply togreygoose

No that's a different Glow protocol 😂

I come from the peptide/biohacking/whatever you want to call it world. Glow in that world is GHK-CU/BPC-157/TB4(500) peptides, usually a twice daily subq injection. I'm confident that this isn't an issue, many thousands using it daily and the amount of copper peptide is fairly small.

CRP wasn't checked as it was an Optimale testosterone blood panel but that's something I'll look out for next time.

I think I'll go for a thyroid panel test and see what I get back from that. Not sure which one yet, there's many to choose from as I'm sure you're aware.

greygoose profile image
greygoose in reply toOneBrainCell

OK, well, that's something I've never heard of before. And what's it supposed to do for you?

Good idea to get full thyroid testing. Make sure that the test includes both FT4 and FT3, and both Hashi's antibodies: TPOab and TgAB. And as many nutrients as possible.

OneBrainCell profile image
OneBrainCell in reply togreygoose

It's for skin, tendon and connective tissue health / regeneration.

Thank you - I'll go through the various testing options and try to find the best one that includes all of those markers without costing a fortune! 👍

greygoose profile image
greygoose in reply toOneBrainCell

You're welcome. :)

ainslie profile image
ainslie

looks like your a bit short on thyroid and maybe testosterone, as others have said you need to test Ft3, your symptoms could be caused by either thyroid or testosterone, your testosterone is probably best half way up range at least. As someone who takes testosterone and thyroid I would say correct the thyroid first and the retest testosterone say a month later. If testosterone still short it’s possible to add testosterone in form of gels, cream or micro dose injections. Taking testosterone will shut down your natural production and my experience is that getting the right testosterone treatment and tuning can be fiddly. Having said that if one is definitely deficient in testosterone then adding some can be a game changer for men and women, I would still start with thyroid though.

OneBrainCell profile image
OneBrainCell in reply toainslie

Yes I've done a lot of research into TRT and appreciate that getting it right can be tricky. Probably looking at daily subQ to keep highs/lows at a minimum.

On the basis of the attached tests one clinic has said "no" (obviously the NHS has) and am enquiring at another. I'm happy to DIY it if required.

But I agree to get the thyroid tests done before and take it from there.

elaar profile image
elaar

As others have said, worth getting your FT3 tested.

It's unlikely you have Primary Hypothyroidism, as your TSH wouldn't be that low with a low FT4/FT3, but there's a possibility you could have Central Hypothyroidism with a Pituatary issue if FT3 turns out to be low.

Worth checking Cholesterol, that's a key indicator.

Low free testosterone is mainly due to your high SHBG, Hypothyroidism *usually* causes a low SHBG, hyperthyroidism is linked to high SHBG (as well as chronic issues, liver, diabetes/insulin etc).

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