A couple of papers re iron/ferritin/hepcidin

[helvella]

A few recent posts regarding more complex and deep iron-related issues and I found these two substantial and complex papers.

For those who need more than the simplest levels of advice and information, they might be worth at least a skim read.

I do not pretend for one moment to have understood the complex information. It needs far more time and attention than I have given it. (And brain power! )

Ferritin - from iron, through inflammation and autoimmunity, to COVID-19.

europepmc.org/article/MED/3...

Effects of Hypoxia and Inflammation on Hepcidin Concentration in Non-Anaemic COVID-19 Patients.

europepmc.org/article/MED/3...

 Buddy195  Maldeerum

[Buddy195 Administrator]

Thankyou for sharing Helvella 👍

[BB001]

Another interesting paper. Thank you. It challenges the widely held belief that ferritin is merely a storage of iron in the body or a market of high inflammation. I haven't read it all, but this bit stood out so far: 'Granick showed that ferritin consisted of 54.5% protein, 12.1% nucleic acid, and 35% ferric oxide-hydroxide'.

Granick S. Structure and physiological functions of ferritin. Physiol. Rev. 1951;31(4):489–511. [Abstract] [Google Scholar]

[arTistapple]

I have absolutely no ide what all this means. However I find it very unsettling. As I said on another post, I feel outside the game. This looks like nothing but bad news.

[pennyannie in reply to arTistapple]

I think it quite normal to be outside the game - oh but - if it were only a game :

Being dyslexic I used to write out any statements I read that I felt said something - I've 4 A4 exercise books full of my ' lines ' - and as I started to get better they all made more sense -

It's likely all down to too low a level of T3 for you as it reads as though you are with that dreadful foggy brain with things going straight over your head and in information overload.

Don't beat yourself up - watch some ----on the TV and turn yourself off - it does all get too much as there appears no straight forward access in the system we face on the ground.

[arTistapple in reply to pennyannie]

Thank you pennyannie. You have come to my rescue on a number of occasions. Clock this up as another one!

[helvella Administrator in reply to arTistapple]

I think we are all outside this game.

While I have deep reservations about AI, I think that the complexity of iron so great that it is simply not feasible for most doctors to understand it all and maintain high awareness of it all over a career life.

Not so long ago, I read a paper which explained that the numbers we get out of iron tests are the result of making hundreds or thousands of actual measurements and analysing and merging that data to be in the same forms as doctors have long been used to. But more detailed analysis might provide far more understanding and need little added to the actual machines. Just a bit more and slightly different processing.

Johannes W Dietrich (and others) have been working on programming models of thyroid function which are based directly on the biochemistry. At least that can be verified to a large extent. AI seems to be able to go off at a tangent and no-one can see why. That is why I tend to prefer to conscious programmer to the statistical AI approaches.

[arTistapple]

Thank you too helvella. I reckon as with pennyannie has spotted, I am in information overload and as someone else commented “in dodgy thyroid thinking mode and decision making” due to lack of T3. Maybe I am better out of the game just at the moment!