Excess t4

[Ganggywaller]

Hi , can anyone help me with this question please. If you have high t4 and very low t3. Is excess t4 excreted from the body or does it cause problems 😃

[PurpleNails Administrator]

Thyroid Hormones are metabolised in a - activation, inactivation, and clearance process. Simply put they are “used up” in the body cells for many processes.

The feedback hypothalamus, pituitary, thyroid would normally regulate levels to prevent excess levels occurring.

Long term high FT4 could potentially have health detriment. It is preferable to have both FT4 & FT3 in range. Doctors might quote impact on heart & bone health although this is most apparent with prolonged significantly high FT4 & FT3

Many say symtoms occurs mostly in line with where the FT3 levels are placed & so you may feel well with high FT4 if FT3 is near to where you feel optimal.

You appear to have a conversation issue. So currently your FT4 is high & FT3 low. Balancing that would be preferable. Your currently being considered for a T3 Trail. Which is the next stage once FT4 at upper level & nutrients are checked to be optimal. (Optimal nutrients can greatly help with conversion)

[tattybogle]

this is not to scare you ... as it's very recent research and not conclusive or even very clear yet, but adding this in case it's useful as an argument for having a trial of T3 with lower T4 levels :

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There are SOME CONCERNS that having high /over rage T4 promotes some kinds of CANCER CELL PROLIFERATION ~ recent research:

healthunlocked.com/thyroidu... levothyroxine-monotherapy-and-cancer

some replies in this post discuss the issue & provide links :

healthunlocked.com/thyroidu... /over-range-t4?

Update : recent video post from jimh111 healthunlocked.com/thyroidu... thyroid-hormones-and-cancer-video

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if my fT3 is relatively low , my fT4 can be very over range 22.7 [7.9-14] without giving me any symptoms of overmedication.... but due to concerns about the above , i'd prefer not to have excessively high fT4 if possible, so am currently trying lower levo dose with a bit of T3 , to try and balance things up a bit.

When the body considers it has 'excess' T4 , it will speed up it's removal using the deiodinase's to convert it into ReverseT3 instead of T3 (reverseT3 is inactive)

[pennyannie]

Hey there again ;

High T4 and low T3 shows a conversion problem - and excess T4 is excreted :

We all make some excess T4 either through times of being unwell, and/ or not converting well the T4 - Levothyroxine and / or having had Graves which generally means over production and higher levels of T4 than is ' normal ' and / or going through RAI thyroid ablation which down regulates the Hypothalamus - Pituitary - Thyroid - feedback system.

Excess T4 is referred to as Reverse T3 - and the body expels this excess T4 through our natural body's system of waste disposal.

I had my Reverse T3 checked back in July2017 when I ran my own first private blood check and my score was way over the accepted range - and as I have Graves and was post RAI thyroid ablation and very unwell this simply confirmed to me that T4 monotherapy was not the best treatment option for me

As you know I was refused both T3 and NDT by my doctor and hospital in 2018 and after a brief episode trying to find my best dose of synthetic T3/T4 decided to switch to NDT which is a fixed ratio of 1/4 - T3/T4 - in each tablet/grain.

I have been well since switching - I doubt my excess T4 is still high - whether it is or not is of no consequence - and I am on approximately 1/2 the dose of T4 I was previously prescribed.

[Ganggywaller in reply to pennyannie]

Thankyou so much pennyannie. I feel better now knowing that .