I found this paper on T3 dose timing interesting, though a tad frustrating that the sample group is young males!
Apologies if posting this link is not appropriate.
Subject: Single Dose T3 Administration: Kinetics and Effects on Biochemical and Physiologic Parameters - PMC
Considering the dose they used was 50 micrograms - which compares to the general idea that 60 micrograms is a typical daily requirement in countries which have 20 microgram tablets; 75 micrograms in countries which have 25 microgram tablets.
So a sizeable dose. And a fairly even effect beyond the transient.
Which is exactly what those who dose daily on T3 say - they don't feel over-dosed as a rule.
Thanks Mothebear. Very interesting. Very simple but powerful bit of info. Truly amazed something so simple does not seem to have been researched and published before. Seemed methodical to me. Like you mention no female participants - even in this day and age seems …….
As a heart patient I was very interested in the timing of the heart’s effects from the dosage.
Hello Thanks for posting the link,
May I ask why you said" though a tad frustrating that the sample group is young males!what difference would male or female make to the results?
Thanks again
Frank
Frank, the reality is the female and male bodies behave very differently. When women have a stroke they have very different symptoms, and why latterly it has been recognised that they historically have had more serious consequences as a result of this not being recognised. Also, men don’t have a physiological menopause that women have. My hot flushes were attributed to the menopause - they were actually a function of my thyroid which was not recognised as the underlying problem. Not something, I suggest, that can happen to a man.
Thank you for your reply.
Female and male bodies are very different and you make a very good point
For a long time clinical trials didnt recruit women especially of childbearing age and unfortunately for far too long treated women as men who just happened not to have male genitalia and who were smaller.
We know of course that there are fundamentally many profound differences between male and female biology. Hormones, chromosomes, body fat composition, muscle mass, the list is endless.
Clinical trials also failed to recruit people of other ethinicities other than white as well and again there are key differences. These differences can cause say a drug that was just tested on white men to behave very differently in women or a man of Afro Caribbean descent.
It seems that at long last researchers have cottoned onto these very serious shortcomings and are now widening the criteria for people to join important research. Its long overdue.
I agree, more research is needed, I was a medical volunteer and it was only white working class males that volunteered, this was in the UK I dont know about other countries. maybe we needed the money more than other groups.
It might be that others weren't invited. I know women were often excluded as there were understandable fears about accidental pregnancy occurring during the trial. But they need to get around these obstacles because research needs to include everyone to be comprehensive.
It was advertised in the newspapers, it would say something like "Healthy male volunteers" never said anything about skin colour but you had to be under 50
Yes, my hot flushes were put down to menopause but looking back I'm convinced it was probably due to thyroid issues. We will never know as one TSH test and they moved on!
Is there a shortage of T3?
T3 of 8.3
Effectiveness of T3
T3
