Is anyone on here taking Thybon?

[Kimkat]

Yesterday I received my first pack of Thybon, so I started this morning with 5mcg taken with my Levo and I am to take the next dose mid afternoon, as instructed by the endocrinologist. If anyone is already taking it, my question is, even though he stated mid afternoon, how many hours between doses do you leave? I have to work in my Ezetimibe for cholesterol which shouldn’t be taken for at least 4/5 hours after . Any info is greatly appreciated.

[Star13]

If you take your statin at night then you should be fine.

[helvella Administrator Thyroid UK in reply to Star13]

Although it is a cholesterol-lowering medicine, Ezetimibe is not a statin!

[Kimkat in reply to helvella]

I was going to ask my gp about that as he wasn’t very happy that I had been prescribed that particular one by the clinical pharmacist but I cant take atorvastatin or rosuvastatin. However since taking ezetimibe my cholesterol has reduced. What exactly is it if it’s not classed a a statin?

[Kimkat in reply to Star13]

Thanks for your reply. I do try not to take my statin at night because I tend to get muscle pain, if I take it earlier I can work it off so to speak but I’ll give it a go as I may be more tolerant to it now

[helvella Administrator Thyroid UK in reply to Kimkat]

It reduces absorption of cholesterol whereas stains act differently.

Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.

en.wikipedia.org/wiki/Ezeti...

The Summary of Product Characteristics for one make includes as below (this tends to be nearly identical regardless of make or dose but might vary a bit):

Ezetimibe monotherapy is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolaemia in whom a statin is considered inappropriate or is not tolerated.

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It appears to have recently increased in price substantially - but still not expensive! See attached image.

And this is a random Patient Information Leaflet:

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Screen shot of dm+d price details

[Kimkat in reply to helvella]

Thanks Helvella. My gp wasn’t happy because he said that Exetimide doesn’t protect the heart and doesn’t help stop strokes but at the end of the day I just couldn’t tolerate it, I could barely lift my legs at one point but he wanted me to take it for at least 3 months for it to settle. That’s all very well and good but I was in constant pain and my pain threshold is high.

[greygoose]

When you raise your FT3 it's doubtful you'll need any sort of medication for cholesterol, because high cholesterol is caused by low FT3.

I could go on for hours about cholesterol and how we're all being scammed by the need to reduce it with drugs, but I'll spare you that and just say that you don't need protecting from cholesterol, because it's the cholesterol that protects you from heart attacks and strokes. Artificially reducing it leaves you vulnerable.

[Kimkat in reply to greygoose]

Yes I r read a few contradictory articles recently about statins and the need to reduce levels, it’s very hard to know what to think .

[greygoose in reply to Kimkat]

Well, given that cholesterol is made in the liver (because the body needs it) and the liver keeps levels steady by making more when you ingest less and vice versa, it rather makes a mockery of the tablets you're taking which reduce the amount of cholesterol the liver absorbs. Because the liver will just make more.

The thing is that when T3 is low, the body cannot process cholesterol correctly, and it tends to build up in the blood.

That said, when they do a blood test for cholesterol, it's not the actual cholesterol they're testing, it's the protein carriers - HDL and LDL - that carry the cholesterol round in the blood to where it's needed, but are backing up due to low T3. So, that makes a mockery of the idea of 'good' and 'bad' cholesterol because it's not even the cholesterol they're measuring.

You cannot live without cholesterol because your whole body and brain are made of it. And without it - or without enough of it - the body cannot carry out repairs and regeneration. Which is why low cholesterol puts you at greater risk of heart attacks and strokes. It's far more dangerous to have low cholesterol than high - in fact, it isn't at all dangerous to have high cholesterol. But it is dangerous to have low T3, and that's another cause of heart attacks.

[Kimkat in reply to greygoose]

Wow that’s a lot to take in, I shall read that a few more times to absorb it but it sounds pretty logical. Thank you

[greygoose in reply to Kimkat]

You're welcome.