Whats the science behind reducing T4 when takin... - Thyroid UK

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Whats the science behind reducing T4 when taking T3?

Ooohmatron profile image
4 Replies

Thanks to some great people on here, I've been taking T3 for about 10 months and Its definitely made a difference. Can't say its helped weight loss or anything, but generally feel much better overall.

Im interested in why a lot of people say to reduce T4 when starting T3. Im currently on 112.5mg of T4 and use 6mg of T3 (quarter of a pill) along with it in the morning.

Would it be worth reducing the T4 to 100mg? Just wondered what the theory was behind reducing the T4.

Thanks

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Ooohmatron profile image
Ooohmatron
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Marz profile image
Marz

Depends on your test results. Many people reduce T4 to prevent over dosing if the T4 is high in range.

Jaydee1507 profile image
Jaydee1507Administrator

Most people on Levo only will have got their FT4 fairly high in range before adding in T3.

On combination therapy most people aim for both FT4 & FT3 being around 70%. So if the FT4 is much above 70% then that person will need to reduce to avoid over replacement.

Hashiboy profile image
Hashiboy

hello Ooohmatron I guess I wondered why you want to change your dose? 112.5 T4 and 5 or 6mcg T3 sounds like something an endo would prescribe. Unless you have symptoms or you have test results that suggest you are over or under that doesn’t sound like a very unusual amount of T4 to me. I’m an 80kg male with not much thyroid tissue left. I take 100 T4 and 15 T3 and feel pretty ok on that - took quite a bit of trial and error to get there. Like other posters suggest, maybe be guided by your symptoms and aim for T4 in range and T3 towards the top of the range. Good luck.

Catseyes235 profile image
Catseyes235

T3 is approximate to 4 x thyroxine so you can roughly work out total T4. Not sure how you take 6 mcg T3 as a quarter tablet. The highest T3 I know is 20 mcg not 24?.?

I was on 125 mcg T4 but dropped this to 100 when introduced T3 but only 5 mcg daily but as this was equivalent to 120 mcg daily I still felt a tad under treated so added 25 mcg T4 3 times a week and now feel I’ve got it right.

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