I have just spent a ridiculous amount of time trying to find a video which describes thyroid hormone binding. Most of the videos I found were terrible - difficult to listen to, superficial, bad (or no) graphics, noisy background music, too complex, scientifically unsound, or several of these!
Eventually I found one which is easy enough to listen to, seems to be at the sort of level I think we can manage, and is more or less scientifically accurate. All in all, I think many of us could watch and listen and get something out of doing so.
(Having viewed so many that are awful, I can't bring myself to criticise this one at all. But, like everything else, it's not perfect.)
Note: As it starts, it isn't obvious that thyroid hormones are going to be such a large proportion of the video. Bear with it!
Endocrinology Hormones Transportation in Blood
Dr. H
If you watched the previous video on Hormones: Chemistry and Receptor Pathways, then you hopefully gained the foundational knowledge to easily understand how chemicals/hormones are transported through the blood.
Hormone transport is directly related to whether the chemical is water soluble or lipid soluble. Water soluble hormones can dissolve in the plasma, whereas lipid soluble hormones need to be bound to a plasma carrier protein.
Thought of it as I watched the video you shared and as he was showing how the hormone produced by the gland went intra-cellular to cross in the blood stream then towards the receptor…
My daughter yesterday asked - do we have blood in all of our body and not just veins… like, when we cut our finger, it bleeds, but where does that blood come from.
I found this awesome open-source, very pictorial and very well organized discussion of our entire circulatory system.
Which talks about how things actually move through the blood stream, cross over and through all the bodies tissues and cells, so get where it needs to go.
So a little academic, but totally eye opening for me as I thought about how our exogenous hormones and supplements make their way to where they need to go.
Brilliant helvella. So good with visuals. Feel ‘closer’ to my hormones now. Interesting about the liver (again) being so central to the process.
Whilst the likes of the connection to Epstein Barre virus gets thrown around, makes me wonder too if the likes of the Hepatitis viruses also have a knock on effect to liver processes and therefore to the ‘efficiency’ of thyroid hormones (and possibly others too).
Don’t answer that. You have definitely done enough work today.
At first I misunderstood the title as thyroid hormone binding is often used to describe the hormone binding to receptors. So, for clarity thyroid hormone is bound to serum transport proteins: TBG, TTR and albumin. To get into the cell it is bound to cellular transport proteins such as MCT8 and OAT1P1C (and others including some we don't know about). T3 then binds to receptors which along with cofactors bind to a response element on the DNA, usually with a vitamin A receptor called 'RXR'.
Sorry, for confusing the issue but beware that thyryoid hormone 'binding' has at least three meanings.
(Also, T3 and mainly T4 can bind to the Integrin αvβ3 Receptor on the cell membrane, this is quite different to the usual action of T3).
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