An interesting snippet. Which is just as well because this is all we ordinary people can view!
Do TFC1 and TFC2 get controlled by TSH exactly the same as each other? Or are the response profiles different? Or do different isoforms of TSH affect them differently?
The thyroid gland under Notch control
Urban Lendahl ORCID: orcid.org/0000-0001-9543-81411
Nature Metabolism volume 5, pages 2037–2038 (2023)Cite this article
A study in Nature Metabolism shows that the thyroid gland contains two subtypes of thyrocytes (the cells that produce thyroid hormones) and reveals a role for Notch signalling in regulating thyrocyte homeostasis and activity, as reduced Notch activity results in hypothyroidism.
Progress on both these frontiers has been made through a recent report in Nature Metabolism by Mosteiro et al.2. The authors first performed a more granular analysis of thyroid gland cellular heterogeneity in the mouse by establishing thyroid cell transcriptomes using single-cell RNA sequencing (scRNA-seq), which led to a discovery of a previously unnoticed thyrocyte heterogeneity. In addition to the more ‘classical’ thyrocyte (denoted TFC1), Mosteiro et al. discovered another subtype — TFC2 — that is endowed with transcriptional features that indicate lower metabolism and more stem-cell-like characteristics. With the mouse transcriptomic data at hand, the authors next generated scRNA-seq data from human thyroids and showed that the TFC1 and TFC2 subtypes could also be identified in the human thyroid.
The rest is firmly behind a paywall.
nature.com/articles/s42255-...
A brief explanation of Notch control! I need to read this...
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