New results confused

[Cade83]

So following on from my previous post I now have my test results.

TSH 1.64 Range 0.27-4.2

FT4 17.5 Range 12-22

FT 3.91 Range 3.1-6.8

T4 101 Range 59-154

TPOAb 109 Range Below 34

TgAB 420 Range Below 115

Folate 16.9 Range 8.83-45

My Creatinine is still high at 108

My eGFR is still low at 57.45 but Thriva go by your birth gender so this is gonna say it’s too low.

What I don’t get is I take B complex with 400ug of folate and that is the recommended daily amount and April last year this was 37.7

I also just remembered you should stop taking b complex before testing because the ones I take have 300ug of biotin in it, is this likely gonna make the results increase or decrease?

What can make folate go down so drastically?

If I go up to 100mcg levothyroxine will this help with my folate absorption and is it likely to help my creatinine and eGFR cause I’m getting worried?

[SlowDragon Administrator]

biotin can falsely affect test results in various ways

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue separate B12 if taking one

Post discussing how biotin can affect test results 

healthunlocked.com/thyroidu...

How much levothyroxine are you currently taking?

75mcg daily?

Try 75mcg 3 days a week and 100mcg 4 days a week

Get a weekly pill dispenser so it’s easy to remember which dose which day

Was test done as recommended timing

Early morning and last dose levothyroxine 24 hours before test

FT4: 17.5 pmol/l (Range 12 - 22)

Ft4 only 55.00% through range

FT3: 3.91 pmol/l (Range 3.1 - 6.8)

Ft3 low at 21.89% through range

shows you have plenty of room for dose increase in levothyroxine

You currently have very poor conversion of Ft4 to Ft3

High thyroid antibodies confirms autoimmune

Optimal vitamin levels should help improve conversion

Are you gluten free and dairy free

This can help too

Low GFR most likely linked to low Ft3 …..and will improve as Ft3 increases

Any testosterone, or hormone blockers at least 4 hours away from levothyroxine

[Cade83 in reply to SlowDragon]

So in high doses it’s likely to impact and give higher FT4 FT3 readings. Most likely unlikely with smaller doses.

I’m currently taking 87.5mcg levothyroxine a day weird I know but at the time felt 75mcg wasn’t enough but 100mcg was too much. So maybe going up to 100mcg a day wouldn’t be such a big jump?

This test was taken early morning probably 26 hours after the last dose.

I keep trying to go dairy and gluten free but it’s not easy. My testosterone is injection every 13 weeks so no problems there.

I guess up to 100mcg daily and test in 6 weeks and maybe vitamins will absorb better I’m not liking the idea of taking more than 400mcg folate a day as that’s the RDA.

[SlowDragon Administrator in reply to Cade83]

I’m currently taking 87.5mcg levothyroxine a day weird I know but at the time felt 75mcg wasn’t enough but 100mcg was too much. So maybe going up to 100mcg a day wouldn’t be such a big jump? 

In which case..yes go up to 100mcg daily

Do you always get same brand of levothyroxine

[Cade83]

Yes always get wockhardt brand, never change.

[SeasideSusie Remembering]

I’m not liking the idea of taking more than 400mcg folate a day as that’s the RDA.

The RDA is for someone who has a sufficient level. You have shown your result as

Folate 16.9 Range 8.83-45

The actual range for folate with Thriva is 8.83-60.8 if you look at the full extent of the green bar or go to the listed results which show result plus range like in the attached image of some Thriva results.

So taking the full range your folate level is 15.53% through range which is low, so you need to supplement bring your level up to at least half way through range then the 400mcg RDA would be appropriate.

[Cade83 in reply to SeasideSusie]

Oh wow yeah I just went to the downloaded results. So yeah that is quite low. I’m gonna have to fine a folate by itself I think. I’m not sure how much I should take now considering I’m already taking 400ug. Maybe once I up my levothyroxine the folate will absorb more.

[SeasideSusie Remembering in reply to Cade83]

When my usually OK folate level inexplicably dropped I used this one

amazon.co.uk/Vegavero%C2%AE...?

It's only 400mcg so if you continue your B Complex and add this then retest when the bottle is finished you can see how much difference it's made.

[Cade83 in reply to SeasideSusie]

Is it actually safe to take 600ug folic acid?

[SeasideSusie Remembering in reply to Cade83]

See my reply above

Considering that when people are folate deficient they're prescribed a course of 5mg folic acid, there's no problem with 600mcg or 800mcg folate for your low level.

[Cade83 in reply to SeasideSusie]

5mg 😲 that’s 5000mcg right?

[SeasideSusie Remembering in reply to Cade83]

Yes.

[Cade83 in reply to SeasideSusie]

I’ve read that it’s mainly for pregnant woman. Are there a lot of people who need this much or is there a reason other than just having hypothyroidism?

[SeasideSusie Remembering in reply to Cade83]

I'm not medically trained, but I believe there can be quite a few reasons for low folate, eg too few folate rich foods, too much alcohol, taking certain other medications, Crohns disease, coeliac disease, some cancers, perhaps more.

Taking extra folate supplement would only be a temporary thing.