Evidence for B12 & folate improving T4 to T3 co... - Thyroid UK

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Evidence for B12 & folate improving T4 to T3 conversion

GW1000 profile image
3 Replies

I was given a link to this really positive account of how improving nutrients has increased T4 to T3 conversion healthunlocked.com/thyroidu....

I am wondering whether there have been any actual studies done on this? More around the effect of improving low (but in range) B12 or folate on thyroid status? I think there are maybe some looking at correcting “actual” deficiencies but is there anything where starting levels are in range?

Would also appreciate any other personal stories or sources of evidence. I want to convince my GP that it’s worth looking (and that if my levels don’t improve with supplementation then I do maybe have the absorption problem I think I have but they won’t test for….)

Many thanks

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GW1000
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SlowDragon profile image
SlowDragonAdministrator

When were vitamin D, folate, ferritin and B12 levels last tested

Saw a previous post from a year or so ago ….

B12 250 approx….so far, far too low

What vitamin supplements are you currently taking

If GP won’t test get vitamins tested privately at least once a year

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

How other member saw how effective improving low B vitamins has been

healthunlocked.com/thyroidu...

Paradoxical B12 deficiency

b12oils.com/paradoxical.htm...

B12 testing….can be unreliable

ncbi.nlm.nih.gov/pmc/articl...

As you have Hashimoto’s are you on strictly gluten free diet and/or dairy free diet

This post …..member had already improved vitamin levels

Then had recently gone gluten free

Splitting dose levothyroxine and/or gluten free diet significantly improved conversion

See my reply right at bottom of thread

healthunlocked.com/thyroidu...

GW1000 profile image
GW1000 in reply to SlowDragon

Hi - and thank you. I had a B12 test two months ago - 265 (187, 883). Had been waiting for my first (and looking like last…) endo appointment hoping that they would think it worth further testing - but they don’t. I have other low B12 symptoms too - didn’t want to jeopardise any tests by already being on a supplement. 265 not low enough for them to sanction further tests even with symptoms - she went to speak to her boss about it and came back with a firm no - definitely not the type of informed discussion I was really hoping for .

They did do a Short Syncathen test but I am assuming it must be negative as I’ve not heard anything a week on. I think their report back to the GP will be “nothing wrong, try SSRIs”. I don’t have anything against SSRIs eventually but not before I’ve tried shifting my B12 again.

I had been taking Igennus Super B- Complex which you had suggested wouldn’t be enough so I now have the Cytoplan sublingual 1mg ready to go once I get the confirmed response back from the endo.

I’m more than convinced it’s the right thing to try but would like a GP to be on board too. Probably unrealistic.

Would I be right in thinking that I should take the Cytoplan Vit B12 AND maybe one Igennus Super B to make sure my Folate keeps up? I should really get that tested first I suppose.

(I think the Igennus one is not recommended now but I still have a supply of them…)

Only other supplement I’m taking is the Better You Vit D + K2. I am mostly gluten free…the odd biscuit or cake! I did try a month of entirely gluten free - didn’t re-test but didn’t feel any difference for it so have returned to allowing myself the odd treat. The mostly gluten free does I think help.

Have also tried - and still am - taking my Levo at night. Again, no noticeable difference. The link about splitting doses is interesting. Will bear that in mind for after the B12 “experiment”.

SlowDragon profile image
SlowDragonAdministrator in reply to GW1000

A high number of people on levothyroxine will always need to supplement to maintain GOOD B vitamins

Yes, initially taking a separate B12 as well as a good quality vitamin B complex

You could get some Thorne Basic vitamin B complex ….they are large capsules. (You can tip powder out if can’t swallow capsule)

…..alternate it with Igennus on alternate days until used up Igennus

Retest after 2-3 months

Once B12 is over 500 ….just continue with vitamin B complex

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate methyl folate supplement and continue separate B12

Low B12 symptoms

b12deficiency.info/signs-an...

B12 sublingual lozenges

amazon.co.uk/Jarrow-Methylc...

cytoplan.co.uk/shop-by-prod...

B12 drops

healthunlocked.com/thyroidu...

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