Article describing safety of T3 treatment on he... - Thyroid UK

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Article describing safety of T3 treatment on heart function

diogenes profile image

This new paper describes T3 effects on heart function and shows little adverse effects

Efficacy and safety of Triiodothyronine (T3) treatment in Cardiac Surgery or Cardiovascular Diseases – a Systematic Review and Meta-analysis of Randomized Controlled Trials

April 2022

Thyroid: official journal of the American Thyroid Association Follow journal

DOI: 10.1089/thy.2021.0609

Mathuri Tharmapoopathy ,Abishan Thavarajah, Ryan PW Kenny, Salman Razvi

18 Replies
helvella profile image
helvellaAdministrator

The abstract (only) is available.

pubmed.ncbi.nlm.nih.gov/354...

jimh111 profile image
jimh111 in reply to helvella

It's free in one year's time! I might try and get a copy from the British Library in a few weeks time.

helvella profile image
helvellaAdministrator in reply to jimh111

Paywalls are utterly immoral.

The idea that the information required to understand and manage our health (up to and including mortality) is locked away doesn't bear any moral or ethical analysis.

Bad enough with papers like this (adopting the relatively recent approach of making them accessible after a certain time), but worse by far when they charge a fortune for ancient papers, or a few lines of correction, or a comment.

Sorry for the rant. (Well, not very sorry. :-) )

Mlinde profile image
Mlinde in reply to helvella

Well no more immoral than privatising healthcare don't you think? Or of having to pay £90 for a blood test because the (Corporate) NHS refuses to do the correct test?

diogenes profile image
diogenes in reply to jimh111

I've put my colleague Prof Hoermann in the picture and asked him to send it in full if he can

diogenes profile image
diogenes in reply to diogenes

Rudolf Hoermann has replied with the paper. I've sent it to Lyn Mynott at TUK headquarters.

beaubeau1121 profile image
beaubeau1121 in reply to jimh111

Hi!I woukd love to purchase/have a fanily cardiac thoracic surgeon review…

How would he acquire as a dr?

Thx so much!

jimh111 profile image
jimh111 in reply to beaubeau1121

Sorry, I'm not a doctor and have no knowledge of cardiology. Maybe another patient can advise.

I looked at some of these studies (studies not meta-analyses) a year or two ago. They were generally inconclusive. Major trauma such as cardiac surgery is associated with 'low T3 syndrome', there is a fall in T3 and a rise in reverse T3 (especially in tissues). Nobody really knows whether giving T3 to correct this is beneficial or harmful. The best study (can't remember it!) seemed to show the low T3 was beneficial for a few days and then harmful. So, it gave a short term protective effect.

I mention the above because this study specifically looks at T3 treatment during cardiac surgery or disease. The effect of T3 therapy on cardiac risk for most patients is a different issue. I always thought that T3 would carry more risk than T4 because giving T3 bypasses the deiodinase mechanisms that can potentially protect the heart, especially during e.g. heart attacks. The meta-analysis you cite here suggests that T3 does not carry extra cardiac risk - even for people with cardiac disease or undergoing cardiac surgery. This is good news.

As regards cardiac risk for people on T3 therapy my post from about a month ago healthunlocked.com/thyroidu... shows that it is levothyroxine monotherapy that is associated with excess cardiac risk rather than T3 / T4 combination therapy. This latest study adds further evidence that T3 / T4 combination therapy is safer than levothyroxine monotherapy on an equivalent dose basis.

I had subacute Thyroiditis in 2017 and my Thyroid could never recover. I also have a work partner who had the same issue.We don't have Hashimotos, we just became hypothyroid because of the sequels of the mumps virus.The thing is, we take levothyroxine and we both have low normal T3 (on the bottom of the range). Her level is 2 (2-4,2) and my level is 2,6 (2-4,2).

We both feel perfectly fine, and have no energy issues, or Brain fog, or weight issues at all.

In my case, I am suffering myclones at night (sudden jerks) and tinnitus, which started before taking levothyroxine (I had elevated TSH for 3 years and they didnt want to medicate me until it reached 10). So, I'm suspecting 2 things:

1. My symptoms are related to being hypo for 3 years before starting levothyroxine (My friend was medicated right after we had the subacute Thyroiditis).

2. Low normal T3 is not the cause of many people's symptoms. The cause is the autoinmune desease itself. As I said, both my friend and I are perfectly well with low normal T3, but our cases are not autoinmune.

Could that be an explanation?

well, the more evidence (like this paper) we get that proves it does no harm , the more people (who do have symptoms) will be able to put your theory to the test.

My hypothyroidism is not autoimmune and low T3 gives me hypo symptoms.

What happened to you? Subacute Thyroiditis?

Never been given any reason. Had a private test which showed conversion issues, DIO2 polymorphism.

It could be iron defficiency or iodine defficiency. Sometimes they mimic hypothyroidism. Did You check?

My thyroid function was completely normal prior to removal due to cancer. T3 in lower half of range makes me feel dreadful and I have no autoimmunity issues at all.

It's a mystery then.

I'm making a copy of that, thank you. Who would do more trials when a 25 mcg Uni-Pharma T3 used to cost about a quarter....if that.

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