I was taking Levothyroxine felt awful so switched to Metavive 1 - but massively tired should I take another?
Metavive 1: I was taking Levothyroxine felt... - Thyroid UK
Metavive 1
![Frannyfree profile image](https://images.hu-production.be/avatars/5f34ecb7b6dd41778b2838bcf582cec4_small@2x_100x100.jpg)
![Frannyfree profile image](https://images.hu-production.be/avatars/5f34ecb7b6dd41778b2838bcf582cec4_small@2x_100x100.jpg)
![SeasideSusie profile image](https://images.hu-production.be/avatars/3f6ac069f2a50ca9d0e85f59f13a7499_small@2x_100x100.jpg)
Frannyfree
It's hard for anyone to offer any suggestions, we don't know anything about you or your diagnosis or what dose of Levo you were taking, for how long, what your test results were like, why you changed to Metavive or how much you are taking of that. There is no information in your profile or your post.
Perhaps if you give us more information we may be able to help.
![SlowDragon profile image](https://images.hu-production.be/avatars/27fbbead1f291333f83bad1f31359fe3_small@2x_100x100.jpg)
Welcome to the forum
How much levothyroxine were you taking
How long at that dose
Did you always get same brand levothyroxine at each prescription
What vitamin supplements are you currently taking
When were vitamin D, folate, ferritin and B12 last tested
What were thyroid and vitamin results and ranges before changing to Metavive
ALWAYS Test thyroid levels as early as possible in morning before eating or drinking anything other than water and last dose levothyroxine 24 hours before test
Sorry- I had a hemi-thyroidectomy in October 2018. Was tested and given Levothyroxjne 25mg. In February this year was retested and levothyrone 75mg. However still massively tired and horrible headaches- and sleep badly.
75mcg is only one step up from starter dose levothyroxine
Unless extremely petite likely to be under medicated
guidelines on dose levothyroxine by weight
Even if we frequently don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or near full replacement dose
NICE guidelines on full replacement dose
nice.org.uk/guidance/ng145/...
1.3.6
Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.
Also here
cks.nice.org.uk/topics/hypo...
gp-update.co.uk/Latest-Upda...
Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months. RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.
For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.
For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).
If you are starting treatment for subclinical hypothyroidism, this article advises starting at a dose close to the full treatment dose on the basis that it is difficult to assess symptom response unless a therapeutic dose has been trialled.
BMJ also clear on dose required
In February this year was retested and levothyrone 75mg
Bloods should have been retested 6-8 weeks after any dose change or brand change in levothyroxine
Which brand of levothyroxine were you taking on 75mcg
Teva brand upsets many people
Teva is only brand that makes 75mcg tablets
For full Thyroid evaluation you need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested.
Very important to test vitamin D, folate, ferritin and B12 at least once year minimum
Low vitamin levels are extremely common, especially with autoimmune thyroid disease (Hashimoto’s or Ord’s thyroiditis)
Autoimmune thyroid disease with goitre is Hashimoto’s
Autoimmune thyroid disease without goitre is Ord’s thyroiditis. Both are autoimmune and generally called Hashimoto’s.
In U.K. medics never call it Hashimoto’s, just autoimmune thyroid disease (and they usually ignore the autoimmune aspect)
Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water and last dose levothyroxine 24 hours before test
On T3 or NDT - or Metavive day before test split daily dose into 3 smaller doses, spread through the day at approx 8 hour intervals, taking last 1/3rd dose 8-12 hours before test
This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)
Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins
List of private testing options
thyroiduk.org/getting-a-dia...
Medichecks Thyroid plus antibodies and vitamins
medichecks.com/products/adv...
Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins by DIY fingerprick test
bluehorizonbloodtests.co.uk...
If you can get GP to test vitamins and antibodies then cheapest option for just TSH, FT4 and FT3
£29 (via NHS private service ) and 10% off down to £26.10 if go on thyroid uk for code
thyroiduk.org/getting-a-dia...
NHS easy postal kit vitamin D test £29 via
If TPO or TG thyroid antibodies are high this is usually due to Hashimoto’s (commonly known in UK as autoimmune thyroid disease). Ord’s is autoimmune without goitre.
About 90% of all primary hypothyroidism in Uk is due to Hashimoto’s. Low vitamin levels are particularly common with Hashimoto’s.
Gluten intolerance is often a hidden issue too. Request coeliac blood test BEFORE considering trial on strictly gluten free diet
Link about thyroid blood tests
thyroiduk.org/getting-a-dia...
Link about Hashimoto’s
thyroiduk.org/hypothyroid-b...
List of hypothyroid symptoms