Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism

[Bolt_Upright]

Interesting paper (remember, I am not a doctor. I have a high school degree):

pubmed.ncbi.nlm.nih.gov/287...

[tattybogle]

link to full paper and results:europeanreview.org/wp/wp-co...

Certainly seems to have several useful effects on untreated sub clinical hypo subjects (with TSH between 3-6) when used for 6 months.

results of myo-inositol + selenium:

reduced TSH from 4.22 to 3.26

increased fT4 from 0.93 to 1.06ng/dl

increased fT3 from 2.71 to 2.83pg/ml

reduced TPOab from 733 to 614

reduced TGab from 355 to 298

symptom score (7 questions ranging from level of pain to the degree of discomfort during swallowing) was improved.

compared to results from selenium alone:

which showed a smaller effect on TSH /fT4 /and did not reduce TGab

I wonder if there are any studies showing if this is a 'dose dependent' effect...and i wonder if/how much the improvements continue if used for longer than 6 months ?

...the paper also suggests possible usefulness of certain types of insotol for PCOS (polycystic ovary syndrome) due to something related to insulin that i don't understand.

[tattybogle in reply to tattybogle]

link to previous post discussing safe dose of selenium and several selenium studies:healthunlocked.com/thyroidu... any-supplements-help-with-hashimotos

[Bolt_Upright]

I guess there is probably some significance to the "sub-clinical" part of "Hashimoto's patients with subclinical hypothyroidism".

[Bolt_Upright]

But then there is this:

In my clinical practice and in listening to what my readers tell me about their own experiences, I have found selenium toxicity to be extremely rare. When taken in therapeutic doses, selenium does not typically have side effects.

But it is always important to understand the flip side of optimal results. While most reported toxicity cases have been associated with industrial accidents and manufacturing errors (29), it is important to at least be aware of the symptoms of selenium toxicity.

Some symptoms of selenium toxicity that have been reported include GI disturbances, hair loss, changes in hair and nails, fatigue, peripheral neuropathy, irritability, garlic-smelling breath, fever, nausea and a jaundice-like yellow tint to the skin.

Potentially serious side effects include liver, kidney and heart problems. At high enough levels, selenium could even cause death.

It’s important to note that selenium may also interact with other supplements and medications, such as cholesterol-lowering statin drugs, antacids, chemotherapy drugs, corticosteroids, niacin, and even birth control pills.

Those with a CBS mutation have difficulty breaking down selenium. (Research has found that selenomethionine needs to be converted into its active form via the CBS gene. So, if this gene is mutated, the body cannot break down selenomethionine properly.) Thus, those with a CBS gene mutation will have more selenium circulating in their body, compared to those without this mutation.

If you know you have the CBS mutation, then regularly monitoring your selenium levels is necessary. If you suspect that you may have this mutation, be sure to test for the CBS gene mutation using a genetic test like the one offered by 23andMe. You’ll also want to check out the Sulfur Toxicity Protocol in the Advanced Protocols section of Hashimoto’s Protocol. We heard from one reader, who had the CBS mutation, and ended up with a selenium toxicity due to this very reason.

Selenium supplements are also associated with a risk of non-melanoma skin cancer (squamous cell carcinoma), so people at high risk of skin cancer should not take these supplements.

In addition, a study by the National Cancer Institute shows that men who already have high concentrations of selenium in their bodies are nearly twice at risk of aggressive prostate cancer if they take selenium supplements.

Furthermore, selenium intake may also cause side effects in those with diabetes. One study found that people who took 200 micrograms a day of selenium were 50 percent more likely to develop type 2 diabetes. So far, it’s unknown whether the selenium actually caused the disease.

thyroidpharmacist.com/artic...