Soy is a very bad thing to consume for everybody - it is not a health food - but especially for hypos. So many things wrong with it, I don't know where to begin. So, I'll start with this post from earlier:
But, the main problem for hypos is that it impedes the uptake of thyroid hormone by the cells. So, you can have good levels in the blood but will still be hypo because it's not getting into the cells.
Are you vegan or dairy free CharleyMae? If so, could you swap to almond milk. Some also find benefit with low lactose dairy milk, if traditional dairy milk causes issues/ inflammation.
There may be good reasons to eat soya products and like any potential foodstuff there are pros and cons depending on individual affinities or sensitivities and the way the foodstuff is produced and processed. But it is a food and there is no evidence it causes hypothyroidism, if there was entire Asian nations would see epidemics of soy related thyroid issues.
Yet another myth..... where’s the evidence for it interfering with cellular membrane thyroid transporters?!?
Published online 2018 Aug 21. doi: 10.1007/s00204-018-2279-8
PMCID: PMC6132702
PMID: 30132047
Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation
Isoflavones may interact with various different components of the thyroid hormone cascade (Fig. 5). In vitro studies have shown that soy isoflavones themselves can act as a substrate for TPO, i.e., they can be iodinated and, therefore, can act as competitive substrates (Divi et al. 1997). This hypothesis is supported by a human study reporting the detection of iodinated isoflavones in human urine after supplementation with isoflavonoids (see “Isoflavone metabolism and concentrations in plasma and target tissues metabolism”; Sosvorova et al. 2012). Furthermore, in the case of an iodine deficiency, direct inhibition of the enzyme by covalent binding of isoflavones has been reported (Fig. 5, A). The half-maximum inhibition (IC50) of TPO of porcine origin is already reached at a genistein and daidzein concentration of approx. 1–10 µM (Divi et al. 1997). Furthermore, genistein but not daidzein was reported to act as a potent inhibitor of human DIO1 (hDIO1) in vitro (Fig. 5, B), while no effect was observed in the case of hDIO2 and hDIO3 (Renko et al. 2015). Another target of isoflavones might be TTR. Genistein and related (iso)flavones are highly effective in inhibiting the binding of TTR to T4 and T3 (KD = 40 nM, equimolar to T4 binding) in serum and CSF (Fig. 5, C). Thus, they may alter the kinetics and distribution of thyroid hormones in the body (Green et al. 2005; Radovic et al. 2006). At the present time it is being discussed whether isoflavones may also influence the transmembrane transport of thyroid hormones by specifically interacting with individual TTHTs such as MCT8, MCT10, LAT1, LAT2 or OATP1C1 (Fig. 5, D; Braun and Schweizer 2015; Johannes et al. 2016; Kinne et al. 2010). Genistein may even act as a powerful chaperone activator of mutated MCT8 in the Allan–Herndon–Dudley syndrome by rescuing expression of the mutated TTHT and favouring its functional expression in the plasma membrane (Braun and Schweizer 2017). Isoflavones may also impact thyroid hormone metabolism, e.g., by inhibiting sulfotransferases (Fig. 5, E; Ebmeier and Anderson 2004).
Hüser S, Guth S, Joost HG, et al. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Arch Toxicol. 2018;92(9):2703-2748. doi:10.1007/s00204-018-2279-8
Thanks for that, it all seems inconclusive and perhaps more a concern if you have subclinical hypothyroidism and are therefore at risk of needing replacement later or are female. pending any better evidence it seems that it you are male and already on replacement therapy soya compounds are of minimal risk and of some benefit.
Soy in the southern Hemisphere is totally different to western!
There's is a natural Fermented Soya that removes any badness
While Western Soya is GMO non Fermented cheap stuff treated with Glyphosates etc so loaded with Phytoestrogens that radicalise in the body creating cancer cells.
We can tolerate wheat while Asian Cultures can't they have soy and Rice.
As i said Asia Soy isn't the same as Western world stuff that is grown Chemically induced with GMO seeds.
Asia has had soya as a staple food for "Years" but not wheat which there bodies can't deal with very well one reason so many struggle with likes of Beer.
Where as were other way round as always had wheat but not Soya.
Soy grown in USA/UK is GMO and "Non" fermented which takes out the nasties like they do in Asia.
Last time i looked China was in southern Hemisphere/Asia!
Got to learn about a lot of this stuff when i did my Sports Coaching Deg's with nutrition
I only consume organic/so no glyphosate, and phytoestrogens are good for me! In fact it because of the effect of thyroid replacement on sex hormone binding globulin I need soy! They's also associated with an immune protective effect against covid!
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